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Objectives <p>There is currently a limited understanding regarding the effect of hepatic steatosis index (HSI) on stroke prognosis. Therefore, we aimed to investigate the effect of HSI on 3-month unfavorable outcomes in adults with acute ischemic stroke (AIS).</p> Methods <p>Between January 2010 and December 2016, a prospective cohort study was conducted involving 1906 AIS patients receiving treatment at a hospital in South Korea. The effect of HSI on 3-month unfavorable outcomes was evaluated using a binary logistic regression model. Smoothed curve fitting and a generalized additive model were also employed to investigate the nonlinear correlation between HSI and unfavorable outcomes.</p> Results <p>Multivariate analysis revealed a significant inverse relationship between HSI and the likelihood of 3-month unfavorable outcomes (OR = 0.97, 95% CI 0.94–1.00, <i>P</i> = 0.028). Particularly, individuals with HSI values of 30–36 had a significantly reduced risk of unfavorable outcomes (OR = 0.59, 95% CI 0.44–0.79, <i>P</i> &lt; 0.001) compared with those with HSI &lt; 30, while this association was not statistically significant when HSI &gt; 36. A nonlinear association was identified, with an inflection point at an HSI of 31.78. For HSI values ≤ 31.78, a significant negative correlation with 3-month unfavorable outcomes was observed (OR = 0.92, 95% CI 0.87–0.96, <i>P</i> = 0.001). However, for HSI values exceeding 31.78, the association between HSI and unfavorable outcomes did not reach statistical significance (OR = 1.01, 95% CI 0.97–1.06, <i>P</i> = 0.595).</p> Conclusions <p>This study demonstrates a statistically significant inverse association between the HSI and 3-month unfavorable outcomes in patients with AIS, observed only when HSI values are below 31.78.</p>

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Non-linear association between hepatic steatosis index and 3-month outcomes in patients with acute ischemic stroke

  • 期刊论文

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  • 发表日期：

    2025年11月25日

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  • Changchun Cao,
  • Mingxing Lou,
  • Jie Jia

摘要

Objectives

There is currently a limited understanding regarding the effect of hepatic steatosis index (HSI) on stroke prognosis. Therefore, we aimed to investigate the effect of HSI on 3-month unfavorable outcomes in adults with acute ischemic stroke (AIS).

Methods

Between January 2010 and December 2016, a prospective cohort study was conducted involving 1906 AIS patients receiving treatment at a hospital in South Korea. The effect of HSI on 3-month unfavorable outcomes was evaluated using a binary logistic regression model. Smoothed curve fitting and a generalized additive model were also employed to investigate the nonlinear correlation between HSI and unfavorable outcomes.

Results

Multivariate analysis revealed a significant inverse relationship between HSI and the likelihood of 3-month unfavorable outcomes (OR = 0.97, 95% CI 0.94–1.00, P = 0.028). Particularly, individuals with HSI values of 30–36 had a significantly reduced risk of unfavorable outcomes (OR = 0.59, 95% CI 0.44–0.79, P < 0.001) compared with those with HSI < 30, while this association was not statistically significant when HSI > 36. A nonlinear association was identified, with an inflection point at an HSI of 31.78. For HSI values ≤ 31.78, a significant negative correlation with 3-month unfavorable outcomes was observed (OR = 0.92, 95% CI 0.87–0.96, P = 0.001). However, for HSI values exceeding 31.78, the association between HSI and unfavorable outcomes did not reach statistical significance (OR = 1.01, 95% CI 0.97–1.06, P = 0.595).

Conclusions

This study demonstrates a statistically significant inverse association between the HSI and 3-month unfavorable outcomes in patients with AIS, observed only when HSI values are below 31.78.