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Background <p>The association between cardiometabolic diseases and the triglyceride-glucose-body mass index (TyG-BMI) has been proved. However, the relationship between the TyG-BMI and cardiometabolic complications in chronic liver disease (CLD) patients has not been clearly elucidated. We aimed to investigate whether the TyG-BMI and its trajectory are associated with cardiometabolic comorbidities, especially Cardiovascular-Kidney-Metabolic syndrome (CKM) in patients with CLD.</p> Methods <p>We obtained data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2020. The exposures were baseline TyG-BMI value at baseline and its change between the first and third waves. The change in TyG-BMI was classified via dynamic time wrapping clustering. The outcomes were CKM syndrome and other cardiometabolic diseases. Adjusted Cox proportional hazards regression was used as the main statistical method.</p> Results <p>There were 765 participants in the CKM cohort, of whom 426 (55.7%) were male and 339 (44.3%) were female. High baseline TyG-BMI values were associated with an HR (95% CI) of 2.404 (1.889–3.060; <i>P</i> &lt; 0.001) for CKM. Compared with those in the steadily low TyG-BMI group, the HR (95%CI) in the steadily high TyG-BMI group was 1.405 (1.051–1.879; <i>P</i> = 0.022), the HR (95% CI) in the increasing TyG-BMI group was 1.602 (1.154–2.223; <i>P</i> = 0.005). Results in other cohorts also confirm the relationship between TyG-BMI and CKM-related diseases.</p> Conclusion <p>Baseline high levels and steadily high or increasing high levels of TyG-BMI are associated with cardiometabolic diseases in CLD patients. Monitoring TyG-BMI might improve the prognosis of patients with CLD.</p>

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Association between the triglyceride glucose-body mass index and cardiometabolic diseases risk in chronic liver disease: a nationwide cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月8日

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  • Tianchen Qian,
  • Pengyao Lin,
  • Qingjing Zhu,
  • Shisong Wang,
  • Yiyun Liu,
  • Jiarong Xie,
  • Lei Xu

摘要

Background

The association between cardiometabolic diseases and the triglyceride-glucose-body mass index (TyG-BMI) has been proved. However, the relationship between the TyG-BMI and cardiometabolic complications in chronic liver disease (CLD) patients has not been clearly elucidated. We aimed to investigate whether the TyG-BMI and its trajectory are associated with cardiometabolic comorbidities, especially Cardiovascular-Kidney-Metabolic syndrome (CKM) in patients with CLD.

Methods

We obtained data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2020. The exposures were baseline TyG-BMI value at baseline and its change between the first and third waves. The change in TyG-BMI was classified via dynamic time wrapping clustering. The outcomes were CKM syndrome and other cardiometabolic diseases. Adjusted Cox proportional hazards regression was used as the main statistical method.

Results

There were 765 participants in the CKM cohort, of whom 426 (55.7%) were male and 339 (44.3%) were female. High baseline TyG-BMI values were associated with an HR (95% CI) of 2.404 (1.889–3.060; P < 0.001) for CKM. Compared with those in the steadily low TyG-BMI group, the HR (95%CI) in the steadily high TyG-BMI group was 1.405 (1.051–1.879; P = 0.022), the HR (95% CI) in the increasing TyG-BMI group was 1.602 (1.154–2.223; P = 0.005). Results in other cohorts also confirm the relationship between TyG-BMI and CKM-related diseases.

Conclusion

Baseline high levels and steadily high or increasing high levels of TyG-BMI are associated with cardiometabolic diseases in CLD patients. Monitoring TyG-BMI might improve the prognosis of patients with CLD.