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Background <p>The prognostic value of mean corpuscular hemoglobin concentration (MCHC) in ICU patients with acute kidney injury (AKI) is unclear.</p> Methods <p>We performed a retrospective multicenter cohort study using MIMIC-IV and eICU–CRD. Adults with AKI and an admission MCHC (first 24&#xa0;h) were included. Outcomes were 30-and 90-day in-hospital mortality. Survival was compared across MCHC quartiles, and Cox models (with restricted cubic splines) estimated adjusted associations.</p> Results <p>Among 111,817 patients (MIMIC-IV <i>n</i> = 54,422; eICU–CRD <i>n</i> = 57,395), higher MCHC was associated with lower mortality. Survival differed across MCHC quartiles (log-rank <i>p</i> &lt; 0.0001 in both cohorts). In adjusted models, the highest vs. lowest MCHC quartile had a lower risk of death (MIMIC-IV HR 0.65, 95% CI 0.60–0.70; eICU–CRD HR 0.62, 95% CI 0.58–0.66). Spline analyses suggested a nonlinear association in MIMIC-IV and an approximately linear association in eICU–CRD.</p> Conclusions <p>Admission MCHC was associated with 30-and 90-day mortality in ICU patients with AKI across two large databases. MCHC may aid risk stratification in this population.</p>

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Association between mean corpuscular hemoglobin concentration and mortality in ICU patients with acute kidney injury: a retrospective multicenter cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Sheng Chen,
  • Xuejin Ye,
  • Lin Guo,
  • Xiaohan Ma,
  • Lingling Wu,
  • Yiwen Li,
  • Minsheng Wu,
  • Rong Tang,
  • Ting Zhang,
  • Peng Jiang,
  • Hongjun Gao,
  • Minghe Jiang

摘要

Background

The prognostic value of mean corpuscular hemoglobin concentration (MCHC) in ICU patients with acute kidney injury (AKI) is unclear.

Methods

We performed a retrospective multicenter cohort study using MIMIC-IV and eICU–CRD. Adults with AKI and an admission MCHC (first 24 h) were included. Outcomes were 30-and 90-day in-hospital mortality. Survival was compared across MCHC quartiles, and Cox models (with restricted cubic splines) estimated adjusted associations.

Results

Among 111,817 patients (MIMIC-IV n = 54,422; eICU–CRD n = 57,395), higher MCHC was associated with lower mortality. Survival differed across MCHC quartiles (log-rank p < 0.0001 in both cohorts). In adjusted models, the highest vs. lowest MCHC quartile had a lower risk of death (MIMIC-IV HR 0.65, 95% CI 0.60–0.70; eICU–CRD HR 0.62, 95% CI 0.58–0.66). Spline analyses suggested a nonlinear association in MIMIC-IV and an approximately linear association in eICU–CRD.

Conclusions

Admission MCHC was associated with 30-and 90-day mortality in ICU patients with AKI across two large databases. MCHC may aid risk stratification in this population.