Scholarlink

Introduction <p>Aconitine poisoning from traditional Chinese medicine is life-threatening, associated with arrhythmias and shock. Early diagnosis and multidisciplinary treatment are essential due to the lack of specific antidotes. This study aimed to present a severe case of aconitine poisoning and to evaluate the effectiveness of combined blood purification and antiarrhythmic therapy, thereby providing practical insights for clinical management.</p> Case summary <p>A 70-year-old man presented with coma, recurrent ventricular arrhythmias, and severe hypotension (nadir: 44/24&#xa0;mmHg) after ingesting Fuzhi (Aconitum taipeicum). Toxicology confirmed high aconitine levels. He was treated with norepinephrine (0.17–0.33&#xa0;μg/kg/min), intravenous amiodarone (150&#xa0;mg bolus over 10–15&#xa0;min, then 1&#xa0;mg/min infusion), electrical cardioversion, and early blood purification (hemoperfusion + CVVH). He regained hemodynamic stability within 24&#xa0;h and fully recovered at 6&#xa0;months (LVEF 59–63%).</p> Conclusions <p>Combined antiarrhythmic therapy and blood purification proved effective. Early recognition and integrated care are key to managing aconitine poisoning.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Combined blood purification and antiarrhythmic therapy for acute aconitine poisoning with refractory arrhythmias: a case-based mechanistic evaluation and treatment strategy optimization

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月29日

查看全文
  • Cheng Yang,
  • Ting Zou,
  • Qian-Hui Zang,
  • Wei Cao,
  • Yuan Suo

摘要

Introduction

Aconitine poisoning from traditional Chinese medicine is life-threatening, associated with arrhythmias and shock. Early diagnosis and multidisciplinary treatment are essential due to the lack of specific antidotes. This study aimed to present a severe case of aconitine poisoning and to evaluate the effectiveness of combined blood purification and antiarrhythmic therapy, thereby providing practical insights for clinical management.

Case summary

A 70-year-old man presented with coma, recurrent ventricular arrhythmias, and severe hypotension (nadir: 44/24 mmHg) after ingesting Fuzhi (Aconitum taipeicum). Toxicology confirmed high aconitine levels. He was treated with norepinephrine (0.17–0.33 μg/kg/min), intravenous amiodarone (150 mg bolus over 10–15 min, then 1 mg/min infusion), electrical cardioversion, and early blood purification (hemoperfusion + CVVH). He regained hemodynamic stability within 24 h and fully recovered at 6 months (LVEF 59–63%).

Conclusions

Combined antiarrhythmic therapy and blood purification proved effective. Early recognition and integrated care are key to managing aconitine poisoning.

Graphical abstract