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Background <p>Critical gaps persist in clinical guidelines and resuscitation strategies for induction and maintenance phase peri-anesthetic cardiac arrest (IM-PACA), urgently necessitating exploration of feasible solutions during anesthesia induction and maintenance periods. This study evaluates a modified cardiopulmonary bypass (CPB) strategy for managing IM-PACA in valvular heart disease (VHD) surgical patients.</p> Methods <p>A retrospective analysis was performed on IM-PACA patients (<i>n</i> = 21) from 1,043 cardiac valve surgeries between March 2019 and January 2022 as the cardiac arrest-resuscitation group (CAR group). Patients who completed normal cardiac valve surgery (<i>n</i> = 84) were randomly selected from the medical record database as the Routine Surgery group (RS group), serving as a benchmark control for the standard efficacy of routine surgery. The CAR group completed surgery after modified cardiopulmonary bypass strategy; the RS group completed surgery as planned. This study reviewed the possible causes of cardiac arrest in the CAR group and performed statistical analysis on surgical time-related metrics (total surgical duration, cardiopulmonary bypass duration, etc.) and postoperative follow-up data (paravalvular leak, cardiac-related complications, etc.) using SPSS 26.0.</p> Results <p>The short-term postoperative survival rate was 95.24% in the CAR group and 100% in the RS group. Baseline characteristics including gender, age, and smoking history showed no significant differences between the two groups (<i>P</i> &gt; 0.05). The CAR group showed a significantly shorter pericardiotomy-to-CPB time (250.00 (205.00–269.50) vs. 512.50 (459.25–563.00) s; <i>P</i> &lt; 0.001), but longer rewarming time (68.00 (63.50–74.50) vs. 48.00 (35.25–61.75) min; <i>P</i> &lt; 0.001), ventilator duration (980.00 (619.00–1106.50) vs. 900.00 (630.00–1103.75) min; <i>P</i> = 0.002), and higher day 2 drainage (190 (157.50–215.00) vs. 105 (71.25–150.00) ml; <i>P</i> &lt; 0.001) compared to the RS group. Other intraoperative and postoperative parameters revealed no statistically significant differences when compared with the RS group (<i>P</i> &gt; 0.05).</p> Conclusions <p>For IM-PACA patients undergoing cardiac valve surgery, the modified cardiopulmonary bypass strategy is an effective rescue method, and the strategy of continuing surgery after resuscitation is completely feasible.</p>

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Cardiac arrest during peri-anesthetic systemic induction and maintenance in valvular heart disease: proceed or abandon? Clinical validation of a modified cardiopulmonary bypass strategy in 21 patients

  • 期刊论文

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  • 发表日期：

    2025年8月29日

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  • Haoshi Wang,
  • Heng Yang,
  • Jia Liu,
  • Haonan Zhang,
  • Yaoguang Feng,
  • Zhengwen Lei

摘要

Background

Critical gaps persist in clinical guidelines and resuscitation strategies for induction and maintenance phase peri-anesthetic cardiac arrest (IM-PACA), urgently necessitating exploration of feasible solutions during anesthesia induction and maintenance periods. This study evaluates a modified cardiopulmonary bypass (CPB) strategy for managing IM-PACA in valvular heart disease (VHD) surgical patients.

Methods

A retrospective analysis was performed on IM-PACA patients (n = 21) from 1,043 cardiac valve surgeries between March 2019 and January 2022 as the cardiac arrest-resuscitation group (CAR group). Patients who completed normal cardiac valve surgery (n = 84) were randomly selected from the medical record database as the Routine Surgery group (RS group), serving as a benchmark control for the standard efficacy of routine surgery. The CAR group completed surgery after modified cardiopulmonary bypass strategy; the RS group completed surgery as planned. This study reviewed the possible causes of cardiac arrest in the CAR group and performed statistical analysis on surgical time-related metrics (total surgical duration, cardiopulmonary bypass duration, etc.) and postoperative follow-up data (paravalvular leak, cardiac-related complications, etc.) using SPSS 26.0.

Results

The short-term postoperative survival rate was 95.24% in the CAR group and 100% in the RS group. Baseline characteristics including gender, age, and smoking history showed no significant differences between the two groups (P > 0.05). The CAR group showed a significantly shorter pericardiotomy-to-CPB time (250.00 (205.00–269.50) vs. 512.50 (459.25–563.00) s; P < 0.001), but longer rewarming time (68.00 (63.50–74.50) vs. 48.00 (35.25–61.75) min; P < 0.001), ventilator duration (980.00 (619.00–1106.50) vs. 900.00 (630.00–1103.75) min; P = 0.002), and higher day 2 drainage (190 (157.50–215.00) vs. 105 (71.25–150.00) ml; P < 0.001) compared to the RS group. Other intraoperative and postoperative parameters revealed no statistically significant differences when compared with the RS group (P > 0.05).

Conclusions

For IM-PACA patients undergoing cardiac valve surgery, the modified cardiopulmonary bypass strategy is an effective rescue method, and the strategy of continuing surgery after resuscitation is completely feasible.