Scholarlink

Background <p>This study aimed to explore associations and causality between excessive daytime sleepiness (EDS), narcolepsy, and hypertension.</p> Methods <p>Publicly available data from the National Health and Nutrition Examination Survey (NHANES), genome-wide association studies (GWAS), and protein quantitative trait locus (pQTL) data sets were used for analysis. Logistic regression models assessed the association between different frequencies of EDS and hypertension, and sex-stratified subgroup analyses were also performed. Bi-directional Mendelian randomization (MR) evaluated the causal effect of narcolepsy on hypertension. Proteome-wide MR and colocalization analyses were conducted to identify potential protein biomarkers and shared genetic variants.</p> Results <p>EDS with different frequencies is associated with hypertension after adjusting for the covariates (rarely: OR = 1.383, 95% CI 1.013–1.889, <i>P</i> = 0.041; sometimes: OR = 1.487, 95% CI 1.105–1.999, <i>P</i> = 0.009; often: OR = 2.041, 95% CI 1.468–2.839, <i>P</i> &lt; 0.001; almost always: OR = 1.581, 95% CI 1.076–2.323, <i>P</i> = 0.020). Subgroup analysis suggested that this effect is significant in males. MR analysis revealed a causal association between narcolepsy and hypertension (OR = 1.038, 95% CI 1.006–1.071, <i>P</i> = 0.019), with no evidence of reverse causality. The protein OLFML3 was causally associated with the increased risk of both narcolepsy (OR = 2.412, 95% CI 1.070–5.436, <i>P</i> = 0.034) and hypertension (OR = 1.237, 95% CI 1.106–1.384, <i>P</i> &lt; 0.001) in proteome-wide MR analysis.</p> Conclusions <p>This study provides integrative evidence of a causal relationship between narcolepsy and hypertension, highlighting OLFML3 as a potential biomarker for both conditions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月16日

查看全文
  • Shenghui Feng,
  • Xiangfei Liu,
  • Yibo Sun,
  • Yaoyao Cai,
  • Shen Chen,
  • Yan Liang

摘要

Background

This study aimed to explore associations and causality between excessive daytime sleepiness (EDS), narcolepsy, and hypertension.

Methods

Publicly available data from the National Health and Nutrition Examination Survey (NHANES), genome-wide association studies (GWAS), and protein quantitative trait locus (pQTL) data sets were used for analysis. Logistic regression models assessed the association between different frequencies of EDS and hypertension, and sex-stratified subgroup analyses were also performed. Bi-directional Mendelian randomization (MR) evaluated the causal effect of narcolepsy on hypertension. Proteome-wide MR and colocalization analyses were conducted to identify potential protein biomarkers and shared genetic variants.

Results

EDS with different frequencies is associated with hypertension after adjusting for the covariates (rarely: OR = 1.383, 95% CI 1.013–1.889, P = 0.041; sometimes: OR = 1.487, 95% CI 1.105–1.999, P = 0.009; often: OR = 2.041, 95% CI 1.468–2.839, P < 0.001; almost always: OR = 1.581, 95% CI 1.076–2.323, P = 0.020). Subgroup analysis suggested that this effect is significant in males. MR analysis revealed a causal association between narcolepsy and hypertension (OR = 1.038, 95% CI 1.006–1.071, P = 0.019), with no evidence of reverse causality. The protein OLFML3 was causally associated with the increased risk of both narcolepsy (OR = 2.412, 95% CI 1.070–5.436, P = 0.034) and hypertension (OR = 1.237, 95% CI 1.106–1.384, P < 0.001) in proteome-wide MR analysis.

Conclusions

This study provides integrative evidence of a causal relationship between narcolepsy and hypertension, highlighting OLFML3 as a potential biomarker for both conditions.