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Objective <p>To investigate the risk factors and prognosis of acute kidney injury (AKI) in elderly patients after surgery based on the Medical Information Mart for Intensive Care IV (MIMIC-IV).</p> Methods <p>A retrospective analysis was conducted using MIMIC-IV data pertaining to aged postoperative patients. By logistic regression analysis models, Kaplan–Meier survival curve and Cox proportional hazards regression model. To evaluate the independent risk variables and prognosis of postoperative AKI in elderly patients.</p> Results <p>A total of 1784 elderly patients who met the inclusion criteria were analyzed. Among them, 1423 developed AKI after surgery. The development of AKI was significantly associated with the use of vasoactive drugs, invasive mechanical ventilation, traumatic surgical procedures, and elevated serum creatinine (Scr) levels within 24&#xa0;h of admission. Cardiac surgery was also highly correlated with postoperative AKI. Factors associated with 28-day mortality in elderly patients with AKI included age ≥ 75&#xa0;years, higher Sequential Organ Failure Assessment (SOFA) scores, elevated blood urea nitrogen (BUN) levels, presence of cerebrovascular disease (CVD), invasive ventilation, neurosurgical procedures, and traumatic surgical procedures.</p> Conclusions <p>Age, Gender, Intervention measures and laboratory indicators can affect the incidence and prognosis of elderly patients’ postoperative AKI. Early identification and timely intervention in patients with these high-risk factors are of practical significance in preventing the occurrence and progression of AKI.</p>

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Risk factors and prognosis of post-surgical acute kidney injury in elderly patients based on the MIMIC-IV database

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月19日

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  • Mengxin Zhang,
  • Jiangwei Zeng,
  • Yanlei Ge,
  • Weibin Chen,
  • Kai Feng,
  • Aibin Cheng,
  • Yu Zhang,
  • Baomin Wang,
  • Jing Bai

摘要

Objective

To investigate the risk factors and prognosis of acute kidney injury (AKI) in elderly patients after surgery based on the Medical Information Mart for Intensive Care IV (MIMIC-IV).

Methods

A retrospective analysis was conducted using MIMIC-IV data pertaining to aged postoperative patients. By logistic regression analysis models, Kaplan–Meier survival curve and Cox proportional hazards regression model. To evaluate the independent risk variables and prognosis of postoperative AKI in elderly patients.

Results

A total of 1784 elderly patients who met the inclusion criteria were analyzed. Among them, 1423 developed AKI after surgery. The development of AKI was significantly associated with the use of vasoactive drugs, invasive mechanical ventilation, traumatic surgical procedures, and elevated serum creatinine (Scr) levels within 24 h of admission. Cardiac surgery was also highly correlated with postoperative AKI. Factors associated with 28-day mortality in elderly patients with AKI included age ≥ 75 years, higher Sequential Organ Failure Assessment (SOFA) scores, elevated blood urea nitrogen (BUN) levels, presence of cerebrovascular disease (CVD), invasive ventilation, neurosurgical procedures, and traumatic surgical procedures.

Conclusions

Age, Gender, Intervention measures and laboratory indicators can affect the incidence and prognosis of elderly patients’ postoperative AKI. Early identification and timely intervention in patients with these high-risk factors are of practical significance in preventing the occurrence and progression of AKI.