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Objective <p>To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA).</p> Methods <p>The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups.</p> Results <p>Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (<i>p</i> &lt; 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (<i>p</i> &lt; 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively.</p> Conclusions <p>Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging.</p>

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Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月28日

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  • Xian-Zhe Qian,
  • Jin-Yu Hu,
  • Yan-Mei Zeng,
  • Hong Wei,
  • Xiao-Yu Wang,
  • Cheng Chen,
  • Qian-Min Ge,
  • Jie Zou,
  • Xian-Mei Zhou,
  • Qian Ling,
  • Liang-Qi He,
  • Xuan Liao,
  • Yi Shao

摘要

Objective

To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA).

Methods

The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups.

Results

Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (p < 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (p < 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively.

Conclusions

Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging.