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Purpose <p>This study aimed to assess the effectiveness of different pulse widths in suppressing bladder overactivity using tibial nerve stimulation (TNS) in cats.</p> Methods <p>Hook electrodes were implanted on the left tibial nerve. Cystometry was conducted by infusing either acetic acid (AA) or normal saline (NS). TNS was applied at intensities of 2–4 times the threshold (T) with pulse widths ranging from 60 to 624 µsec. Cystometrograms were used to evaluate the impact of different pulse widths on the micturition reflex.</p> Results <p>Bladder capacity (BC) was significantly reduced to 49.71% ± 6.76% of the NS control level (8.58 ± 1.70&#xa0;mL) due to AA-induced bladder overactivity (<i>P</i> &lt; 0.001). During AA infusion, TNS at pulse widths of 60, 210, 420, and 624 µsec significantly increased BC to 70.65% ± 9.06%, 73.22% ± 6.28%, 73.79% ± 8.56%, and 76.25% ± 7.95% of the NS control level, respectively (<i>P</i> &lt; 0.001). No significant differences were observed among the four pulse widths (<i>P</i> &gt; 0.05). The threshold intensity (T) was higher at 60 µsec than at 624 µsec (<i>P</i> &lt; 0.01), while T at 210 µsec, 420 µsec, and 624 µsec showed no significant differences (<i>P</i> &gt; 0.05).</p> Conclusions <p>All four pulse widths demonstrated inhibitory effects on bladder overactivity. However, no significant differences were observed among the four pulse widths.</p>

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Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats

  • 期刊论文

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  • 发表日期：

    2025年3月19日

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  • Dongsheng Shang,
  • Haoyu Sun,
  • Han Deng,
  • Gongyue Liu,
  • Limin Liao,
  • Xing Li

摘要

Purpose

This study aimed to assess the effectiveness of different pulse widths in suppressing bladder overactivity using tibial nerve stimulation (TNS) in cats.

Methods

Hook electrodes were implanted on the left tibial nerve. Cystometry was conducted by infusing either acetic acid (AA) or normal saline (NS). TNS was applied at intensities of 2–4 times the threshold (T) with pulse widths ranging from 60 to 624 µsec. Cystometrograms were used to evaluate the impact of different pulse widths on the micturition reflex.

Results

Bladder capacity (BC) was significantly reduced to 49.71% ± 6.76% of the NS control level (8.58 ± 1.70 mL) due to AA-induced bladder overactivity (P < 0.001). During AA infusion, TNS at pulse widths of 60, 210, 420, and 624 µsec significantly increased BC to 70.65% ± 9.06%, 73.22% ± 6.28%, 73.79% ± 8.56%, and 76.25% ± 7.95% of the NS control level, respectively (P < 0.001). No significant differences were observed among the four pulse widths (P > 0.05). The threshold intensity (T) was higher at 60 µsec than at 624 µsec (P < 0.01), while T at 210 µsec, 420 µsec, and 624 µsec showed no significant differences (P > 0.05).

Conclusions

All four pulse widths demonstrated inhibitory effects on bladder overactivity. However, no significant differences were observed among the four pulse widths.