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Background <p>Healthcare-associated infections (HAIs) are a global public health issue and a major threat to patient safety. This study aimed to estimate the prevalence of HAIs and antimicrobial use in a tertiary hospital in Shanghai, China.</p> Methods <p>Point-prevalence surveys were conducted annually from 2012 to 2023. All inpatients present on the survey day were included. Data were analyzed to identify trends and patterns in the prevalence of HAIs and antimicrobial use.</p> Results <p>The overall prevalence of HAIs was 3.97%, with significant variations observed across departments, age groups and patient populations, whether undergoing surgery or not. There was a significant upward trend in surgical wards from 3.97% in 2012 to 4.82% in 2023 (<i>β</i> = 0.135, <i>P</i> = 0.003). The prevalence of catheter-associated urinary tract infection showed a significant decreasing trend (<i>β</i> = − 0.032, <i>P</i> &lt; 0.001). There was an increasing trend in the proportion of patients receiving single-agent antimicrobial use for prophylactic and therapeutic purposes. The most frequently isolated pathogens were <i>Acinetobacter baumannii</i>, <i>Klebsiella pneumoniae</i>, and <i>Escherichia coli</i>, which exhibited high rates of resistance to carbapenems.</p> Conclusion <p>Despite some progress, challenges regarding HAIs and antimicrobial resistance persist in a tertiary care setting. The findings highlight the necessity for targeted infection control measures and robust antimicrobial stewardship programs to mitigate the burden of HAIs and optimize antimicrobial use.</p>

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Point-prevalence of healthcare-associated infections and antimicrobial use in a tertiary hospital in Shanghai, China: 2012–2023

  • 期刊论文

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  • 发表日期：

    2026年1月17日

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  • Ya Yang,
  • Ruihong Shen,
  • Feng Lu,
  • Bingchao Cai,
  • Mei Huang,
  • Jiayan Ding,
  • Yayun Yuan,
  • Xiaobo Gui,
  • Sijin Yan,
  • Luyao Li,
  • Shiwen Huang,
  • Xiaofang Fu,
  • Haiqun Ban,
  • Xingrong Gong,
  • Zheng Wang

摘要

Background

Healthcare-associated infections (HAIs) are a global public health issue and a major threat to patient safety. This study aimed to estimate the prevalence of HAIs and antimicrobial use in a tertiary hospital in Shanghai, China.

Methods

Point-prevalence surveys were conducted annually from 2012 to 2023. All inpatients present on the survey day were included. Data were analyzed to identify trends and patterns in the prevalence of HAIs and antimicrobial use.

Results

The overall prevalence of HAIs was 3.97%, with significant variations observed across departments, age groups and patient populations, whether undergoing surgery or not. There was a significant upward trend in surgical wards from 3.97% in 2012 to 4.82% in 2023 (β = 0.135, P = 0.003). The prevalence of catheter-associated urinary tract infection showed a significant decreasing trend (β = − 0.032, P < 0.001). There was an increasing trend in the proportion of patients receiving single-agent antimicrobial use for prophylactic and therapeutic purposes. The most frequently isolated pathogens were Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli, which exhibited high rates of resistance to carbapenems.

Conclusion

Despite some progress, challenges regarding HAIs and antimicrobial resistance persist in a tertiary care setting. The findings highlight the necessity for targeted infection control measures and robust antimicrobial stewardship programs to mitigate the burden of HAIs and optimize antimicrobial use.