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Background/introduction <p>Antipseudomonal antibiotics are frequently used in patients admitted to hospitals. Many of these substances are classified as a reserve or watch status by the WHO. Inappropriate risk assessment of invasive detection of <i>P. aeruginosa</i> (PAE) can be a reason for overuse of antipseudomonal antibiotics. Therefore it is important to define relevant and specific risk factors for invasive PAE detection.</p> Objective <p>The objective of this study was to identify risk factors for invasive detection of PAE in patients upon hospital admission.</p> Methods <p>All patients 18 years of age and older with a detection of PAE and/or Enterobacterales in clinical samples taken within 48&#xa0;h of admission to one of the hospitals of Charité Universitätsmedizin Berlin between 2015 and 2020 were included into this retrospective cohort study.</p> Results <p>Overall, we included a total of 27,710 patients. In 3,764 (13.6%) patients PAE was detected in clinical samples taken within 48&#xa0;h after admission. The most frequently detected Enterobacterales was <i>E. coli</i> in 14.142 (51%) patients followed by <i>Klebsiella spp</i>. in 4.432 (16%) patients. Multivariable regression analysis identified that prior colonisation with a multi drug resistant PAE or detection of a PAE in clinical samples during a previous hospitalisation increased the risk for invasive detection of PAE (OR 39.41; 95% CI 28.54–54.39) and OR 7.87 (95% CI 6.60–9.38) respectively. Admission to a specialised ward for patients with cystic fibrosis was associated with an increased risk (OR 26.99; 95% CI 20.48–35.54). Presence of chronic pulmonary disease (OR 2.05; 95% CI 1.85–2.26), hemiplegia (OR 2.16; 95% CI 1.90–2.45) and male gender (OR 1.60; 95% CI 1.46–1.75) were associated with a modest increase in risk for presence of PAE.</p> Conclusion <p>Patients with a prior detection of <i>P. aeruginosa</i> or admission to a cystic fibrosis ward had the highest risk for invasive detection of <i>P. aeruginosa.</i> Adherence to specific risk scores based on local risk factors could help to optimize prescription of anti-pseudomonal antibiotics that categorized as reserve and watch.</p>

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Risk factors for detection of Pseudomonas aeruginosa in clinical samples upon hospital admission

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月25日

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  • Romeo Reyle,
  • Frank Schwab,
  • Selin Saydan,
  • Michael Behnke,
  • Rasmus Leistner,
  • Petra Gastmeier,
  • Christine Geffers,
  • Tobias Siegfried Kramer

摘要

Background/introduction

Antipseudomonal antibiotics are frequently used in patients admitted to hospitals. Many of these substances are classified as a reserve or watch status by the WHO. Inappropriate risk assessment of invasive detection of P. aeruginosa (PAE) can be a reason for overuse of antipseudomonal antibiotics. Therefore it is important to define relevant and specific risk factors for invasive PAE detection.

Objective

The objective of this study was to identify risk factors for invasive detection of PAE in patients upon hospital admission.

Methods

All patients 18 years of age and older with a detection of PAE and/or Enterobacterales in clinical samples taken within 48 h of admission to one of the hospitals of Charité Universitätsmedizin Berlin between 2015 and 2020 were included into this retrospective cohort study.

Results

Overall, we included a total of 27,710 patients. In 3,764 (13.6%) patients PAE was detected in clinical samples taken within 48 h after admission. The most frequently detected Enterobacterales was E. coli in 14.142 (51%) patients followed by Klebsiella spp. in 4.432 (16%) patients. Multivariable regression analysis identified that prior colonisation with a multi drug resistant PAE or detection of a PAE in clinical samples during a previous hospitalisation increased the risk for invasive detection of PAE (OR 39.41; 95% CI 28.54–54.39) and OR 7.87 (95% CI 6.60–9.38) respectively. Admission to a specialised ward for patients with cystic fibrosis was associated with an increased risk (OR 26.99; 95% CI 20.48–35.54). Presence of chronic pulmonary disease (OR 2.05; 95% CI 1.85–2.26), hemiplegia (OR 2.16; 95% CI 1.90–2.45) and male gender (OR 1.60; 95% CI 1.46–1.75) were associated with a modest increase in risk for presence of PAE.

Conclusion

Patients with a prior detection of P. aeruginosa or admission to a cystic fibrosis ward had the highest risk for invasive detection of P. aeruginosa. Adherence to specific risk scores based on local risk factors could help to optimize prescription of anti-pseudomonal antibiotics that categorized as reserve and watch.