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Background <p>Glycocalyx degradation, reflected by syndecan-1 shedding, is implicated in microcirculatory dysfunction and inflammatory responses. The present study aimed to assess early postoperative changes in plasma syndecan-1 levels following major thoracic and abdominal surgery, and their association with 30-days postoperative complications.</p> Methods <p>A prospective, single-center observational cohort study included 107 patients. Syndecan-1 levels were measured preoperatively and two and 18&#xa0;h after surgery. Associations with clinical and intraoperative variables were evaluated using univariate linear regression. The predictive performance of syndecan-1 for major complications and mortality within 30 days was assessed via receiver operating characteristic (ROC) analysis.</p> Results <p>The median syndecan-1 values after two hours of surgery were 958 pg/mL (IQR 654–2665). No significant associations were found with comorbidities, surgical approach, intraoperative factors, or complications (all <i>p</i> &gt; 0.05). Syndecan-1 showed poor predictive performance for major complications and mortality within 30 days (AUC 0.52; 95% CI: 0.40–0.63; <i>p</i> = 0.765).</p> Conclusion <p>Syndecan-1 levels vary widely postoperatively and are not associated with key perioperative variables or outcomes. These findings suggest limited utility of syndecan-1 as a biomarker for perioperative risk stratification in this setting.</p>

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Early plasma syndecan-1 dynamics and their prognostic value in major thoracic and abdominal surgery: a prospective observational study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月2日

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  • Lysha M. Laurens,
  • María Alonso,
  • Janire Perurena,
  • Marcos de Miguel,
  • Ekaterine Popova,
  • Miriam de Nadal

摘要

Background

Glycocalyx degradation, reflected by syndecan-1 shedding, is implicated in microcirculatory dysfunction and inflammatory responses. The present study aimed to assess early postoperative changes in plasma syndecan-1 levels following major thoracic and abdominal surgery, and their association with 30-days postoperative complications.

Methods

A prospective, single-center observational cohort study included 107 patients. Syndecan-1 levels were measured preoperatively and two and 18 h after surgery. Associations with clinical and intraoperative variables were evaluated using univariate linear regression. The predictive performance of syndecan-1 for major complications and mortality within 30 days was assessed via receiver operating characteristic (ROC) analysis.

Results

The median syndecan-1 values after two hours of surgery were 958 pg/mL (IQR 654–2665). No significant associations were found with comorbidities, surgical approach, intraoperative factors, or complications (all p > 0.05). Syndecan-1 showed poor predictive performance for major complications and mortality within 30 days (AUC 0.52; 95% CI: 0.40–0.63; p = 0.765).

Conclusion

Syndecan-1 levels vary widely postoperatively and are not associated with key perioperative variables or outcomes. These findings suggest limited utility of syndecan-1 as a biomarker for perioperative risk stratification in this setting.