Background <p>Suicide is a major public health concern in the U.S., with notable racial disparities. Historically, non-Hispanic Whites (NHW) had the highest suicide rates, but recent trends show increasing rates among non-Hispanic Blacks (NHB), particularly youth. Geographic variations may influence these disparities, yet little research explores this aspect. This study examines regional differences in suicide rates among non-Hispanic Blacks and non-Hispanic Whites from 2010 to 2020. Additionally, it investigates whether strong social support networks, particularly in states with higher proportions of non-Hispanic Black residents, are associated with lower suicide rates. Findings may inform targeted interventions to address racial disparities in suicide risk.</p> Methods <p>Age-adjusted suicide rates (per 100,000) were collected from the CDC WONDER database for underlying causes of death for the 34 US states and D.C. that had data on suicide rates for the NHW and NHB populations between 2010 and 2020. Additionally, we calculated Cohen’s <i>d</i>- by state. Finally, we used multivariate regression model to estimate the relationship between the share of NHBs in a state’s population and their suicide rate.</p> Results <p>For NHWs, the highest rates were observed in Nevada, Colorado, and Arizona. In contrast, NHB suicide rates were highest in Iowa and Kansas. The gap between NHW and NHB suicide rates was most pronounced in Florida, New York and Mississippi. Additionally, we found a negative association between the share of NHBs in a state’s population and suicide rates among this group.</p> Conclusions <p>The findings underscore the need for race-specific and state-specific public health interventions to reduce the burden of suicide mortality.</p>