Scholarlink

Background <p>Bodyweight increase since early adulthood is a risk factor for lifestyle-related diseases and may be a predictor of mobility decline. Locomotive syndrome (LS) is a condition characterized by reduced mobility due to musculoskeletal impairments, and its severity reflects the degree of mobility decline. This study aimed to investigate the association between a bodyweight increase of ≥ 10&#xa0;kg since age 20 and the progression of LS severity.</p> Methods <p>This was a 7-year longitudinal observational study including 10,316 Japanese adults aged ≥ 40 years who underwent health checkups in 2016 and 2023. Total bodyweight increase from age 20 to baseline was self-reported. Based on established cut-off values, LS severity was assessed using the 25-question Geriatric Locomotive Function Scale (GLFS-25), the two-step test, the stand-up test, and total assessment according to predefined criteria. LS progression was defined as a worsening by at least one LS severity category from 2016 to 2023; all others, including those with persistently non-LS status, were classified as non-progression. A multivariate logistic regression analysis was performed to examine associations, adjusting for potential confounders. Considering age-related weight changes in older adults, a sensitivity analysis was performed, restricted to participants aged 40–65 years (<i>n</i> = 9994).</p> Results <p>The mean age of the participants was 50.0 years (range, 40–84 years), and 4044 (39.2%) were female. Of the 10,316 participants, 3530 (34.2%) showed an increase in body weight from age 20 to baseline of ≥ 10&#xa0;kg. A bodyweight increase of ≥ 10&#xa0;kg was significantly associated with the progression of LS severity assessed by the GLFS-25 (odds ratio [OR]: 1.38, 95% confidence interval [CI]: 1.11–1.71), the stand-up test (OR: 1.20, 95% CI: 1.00–1.45), and the total assessment (OR: 1.23, 95% CI: 1.05–1.44), but not by the two-step test (OR: 0.99, 95% CI: 0.70–1.42). The sensitivity analysis results were generally consistent, indicating the robustness of our findings.</p> Conclusions <p>A bodyweight increase of ≥ 10&#xa0;kg since early adulthood was associated with the progression of LS severity assessed by the GLFS-25, the stand-up test, and the total assessment. Therefore, midlife weight management is crucial to preventing mobility decline at older age.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bodyweight increase since early adulthood as a risk factor for mobility decline: a 7-year longitudinal study of 10,316 Japanese adults aged ≥ 40 years

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月8日

查看全文
  • Takaomi Kobayashi,
  • Keiko Yamada,
  • Satoshi Yamaguchi,
  • Hideaki Ishibashi,
  • Tomoyuki Arai,
  • Yasuhiro Morita,
  • Yoichi M. Ito,
  • Tadatsugu Morimoto,
  • Takashi Ohe,
  • Ryo Nakagawa

摘要

Background

Bodyweight increase since early adulthood is a risk factor for lifestyle-related diseases and may be a predictor of mobility decline. Locomotive syndrome (LS) is a condition characterized by reduced mobility due to musculoskeletal impairments, and its severity reflects the degree of mobility decline. This study aimed to investigate the association between a bodyweight increase of ≥ 10 kg since age 20 and the progression of LS severity.

Methods

This was a 7-year longitudinal observational study including 10,316 Japanese adults aged ≥ 40 years who underwent health checkups in 2016 and 2023. Total bodyweight increase from age 20 to baseline was self-reported. Based on established cut-off values, LS severity was assessed using the 25-question Geriatric Locomotive Function Scale (GLFS-25), the two-step test, the stand-up test, and total assessment according to predefined criteria. LS progression was defined as a worsening by at least one LS severity category from 2016 to 2023; all others, including those with persistently non-LS status, were classified as non-progression. A multivariate logistic regression analysis was performed to examine associations, adjusting for potential confounders. Considering age-related weight changes in older adults, a sensitivity analysis was performed, restricted to participants aged 40–65 years (n = 9994).

Results

The mean age of the participants was 50.0 years (range, 40–84 years), and 4044 (39.2%) were female. Of the 10,316 participants, 3530 (34.2%) showed an increase in body weight from age 20 to baseline of ≥ 10 kg. A bodyweight increase of ≥ 10 kg was significantly associated with the progression of LS severity assessed by the GLFS-25 (odds ratio [OR]: 1.38, 95% confidence interval [CI]: 1.11–1.71), the stand-up test (OR: 1.20, 95% CI: 1.00–1.45), and the total assessment (OR: 1.23, 95% CI: 1.05–1.44), but not by the two-step test (OR: 0.99, 95% CI: 0.70–1.42). The sensitivity analysis results were generally consistent, indicating the robustness of our findings.

Conclusions

A bodyweight increase of ≥ 10 kg since early adulthood was associated with the progression of LS severity assessed by the GLFS-25, the stand-up test, and the total assessment. Therefore, midlife weight management is crucial to preventing mobility decline at older age.