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Background <p>Previous studies have proven the relationship between frailty and major adverse cardiovascular and cerebrovascular events (MACCE). However, the potential mechanisms need to be further explored. This study aimed to investigate the mediating effect of lipid accumulation products (LAP) in the relationship between frailty and MACCE.</p> Methods <p>This study recruited 7901 participants aged 45 and above from wave 2011 and 2018 of the China Longitudinal Study of Health and Retirement (CHARLS). Logistic regression models were employed to examine the relationship between frailty and MACCE and the mediating effects of LAP, using the bootstrap method to confirm path effects.</p> Results <p>Frailty group presented the highest risk of MACCE (OR 1.07, 95% CI 1.03–1.10). Frailty directly impacted MACCE (β = 0.045, <i>P</i> = 0.007). Frailty had a significant effect on LAP (β = 12.21, <i>P</i> &lt; 0.01), while LAP had a significant impact on MACCE (β = 11.14, <i>p</i> = 0.014). The mediation effect of LAP accounted for 1.7% of the total effect regarding the frailty with MACCE.</p> Conclusion <p>LAP mediate the relationship between frailty and MACCE. Our findings suggest that instructing frailty patients to have a reasonable diet and exercise to control LAP at a low level may be an effective measure to reduce MACCE.</p>

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The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月12日

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  • Zhoucheng Kang,
  • Yongli Ye,
  • Hao Xiao,
  • Lingling Liu

摘要

Background

Previous studies have proven the relationship between frailty and major adverse cardiovascular and cerebrovascular events (MACCE). However, the potential mechanisms need to be further explored. This study aimed to investigate the mediating effect of lipid accumulation products (LAP) in the relationship between frailty and MACCE.

Methods

This study recruited 7901 participants aged 45 and above from wave 2011 and 2018 of the China Longitudinal Study of Health and Retirement (CHARLS). Logistic regression models were employed to examine the relationship between frailty and MACCE and the mediating effects of LAP, using the bootstrap method to confirm path effects.

Results

Frailty group presented the highest risk of MACCE (OR 1.07, 95% CI 1.03–1.10). Frailty directly impacted MACCE (β = 0.045, P = 0.007). Frailty had a significant effect on LAP (β = 12.21, P < 0.01), while LAP had a significant impact on MACCE (β = 11.14, p = 0.014). The mediation effect of LAP accounted for 1.7% of the total effect regarding the frailty with MACCE.

Conclusion

LAP mediate the relationship between frailty and MACCE. Our findings suggest that instructing frailty patients to have a reasonable diet and exercise to control LAP at a low level may be an effective measure to reduce MACCE.