RETRACTED ARTICLE: Network pharmacology and molecular docking of cyclomastopathy Chinese medicine formula

In this study, tissue pharmacology and molecular docking methods were used to investigate the therapeutic effect of cyclomastopathy on “Chinese Thorowax Root–angelica” and its mechanism. The active compounds in “Chinese Thorowax Root–angelica” and their corresponding targets were analysed using the TCMSP database. In this paper, anti-inflammatory targets were obtained from GeneCards, OMIM and other databases, and the component network of the target pathway was constructed using Cytoscape software. On this basis, a new protein–protein interaction network model was established. In this paper, the concentrations of GO and KEGG were analysed using PPI analysis of intersection targets. The results showed that AKT1 was strongly associated with 15 active substances, 17 TNF, 11 TP53, 13 VEGFA, and 11 IL-6. It was found that the compatible active substance of Chinese Thorowax Root–angelica had a strong binding affinity with the main target. Drug-active substances and corresponding targets are relevant for the treatment of cyclomastopathy.