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Background <p>Despite the unknown mechanisms of coronary slow flow (CSF), several studies have investigated the role of inflammation in CSF pathogenesis and evaluated the hs-CRP levels in these patients. Our meta-analysis aims to resolve the controversy in the results and draw a conclusion.</p> Methods <p>All studies measuring hs-CRP in patients with CSF and controls were included after a systematic search.&#xa0;A random-effects meta-analysis was employed to calculate standardized mean differences, considering heterogeneity among the studies. The methodological quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS).</p> Results <p>Out of the 299 records, 31 cross-sectional studies were included in the systematic review. The meta-analysis of these eligible cross-sectional studies revealed a significant association between CSF and hs-CRP (MD: 1.95 mg/L; 95% CI, 1.03 to 2.88;&#xa0;<i>p</i> ≤ 0.0001). The heterogeneity was considerable among studies. Additionally, sensitivity analyses indicated that the meta-analysis models were robust.</p> Conclusion <p>This meta-analysis suggests that patients with CSF exhibit significantly elevated hs-CRP levels compared to healthy controls, supporting the role of hs-CRP as a state marker of the disease.</p> Systematic review registration <p>CRD42023359516</p>

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The relationship between high-sensitivity C-reactive protein and coronary slow flow: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月25日

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  • Simin Zare,
  • Navid Omidkhoda,
  • Vahid Ghavami,
  • Amir Hooshang Mohammadpour,
  • Theodoros Kelesidis,
  • Mohammad Reza Khojasteh,
  • Sara Samadi

摘要

Background

Despite the unknown mechanisms of coronary slow flow (CSF), several studies have investigated the role of inflammation in CSF pathogenesis and evaluated the hs-CRP levels in these patients. Our meta-analysis aims to resolve the controversy in the results and draw a conclusion.

Methods

All studies measuring hs-CRP in patients with CSF and controls were included after a systematic search. A random-effects meta-analysis was employed to calculate standardized mean differences, considering heterogeneity among the studies. The methodological quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS).

Results

Out of the 299 records, 31 cross-sectional studies were included in the systematic review. The meta-analysis of these eligible cross-sectional studies revealed a significant association between CSF and hs-CRP (MD: 1.95 mg/L; 95% CI, 1.03 to 2.88; p ≤ 0.0001). The heterogeneity was considerable among studies. Additionally, sensitivity analyses indicated that the meta-analysis models were robust.

Conclusion

This meta-analysis suggests that patients with CSF exhibit significantly elevated hs-CRP levels compared to healthy controls, supporting the role of hs-CRP as a state marker of the disease.

Systematic review registration

CRD42023359516