Background <p>Improving the nutrition of patients with lung cancer is a major public health concern. Malnutrition and other nutritional issues affect up to 80% of cancer patients with lung cancer and negatively impact their quality of life. Yet, there is no adequate information regarding what types of interventions are most effective for improving nutrition and survivorship outcomes in patients with lung cancer. This systematic review and meta-analysis will determine the effectiveness of interventions in improving nutritional status, quality of life, and survival among patients with lung cancer.</p> Methods <p>We will search the following databases and websites (from inception untill March 2025): CINAHL, MedlinePlus, PubMed, ScienceDirect, and Web of Science. We will search for gray literature on the following websites: the American Lung Association, Lung Cancer Foundation of America, Lung Cancer Research Foundation, American Cancer Society, and the National Cancer Institute. We will include studies that used an experimental or rigorous quasi-experimental design. Two reviewers will independently screen all articles and categorize data using a data abstraction tool. The two reviewers will resolve disagreements through discussion. The risk of bias in included studies will be assessed using the Cochrane risk-of-bias tool 2. All statistical analyses will be conducted on STATA.</p> Discussion <p>This systematic review and meta-analysis will evaluate both published and unpublished literature to determine the types of nutritional interventions that are associated with improved quality of life and survival among patients with lung cancer. In addition, it will identify strategies that can be incorporated into nutritional care protocols for patients with lung cancer to reduce their risk of malnutrition and treatment effectiveness.</p> Systematic review registration <p>The protocol has been registered on the International Prospective Register of Systematic Reviews (ID: 592,679).</p>