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<p>Lactate is a crucial product of cancer metabolism, creating an acidic environment that supports cancer growth and acts as a substrate for lactylation. Lactylation, a newly discovered epigenetic modification, plays a vital role in cancer cell signaling, metabolic reprogramming, immune response, and other functions. This review explores the regulation of lactylation, summarizes recent research on its role in cancers, and highlights its application in cancer drug resistance and immunotherapy. These insights aim to provide new avenues for targeting lactylation in cancer therapy.</p>

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Mechanism and application of lactylation in cancers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月4日

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  • Jiewen Wang,
  • Mingjing Peng,
  • Linda Oyang,
  • Mengzhou Shen,
  • Shizhen Li,
  • Xianjie Jiang,
  • Zongyao Ren,
  • Qiu Peng,
  • Xuemeng Xu,
  • Shiming Tan,
  • Longzheng Xia,
  • Wenjuan Yang,
  • Haofan Li,
  • Nayiyuan Wu,
  • Yanyan Tang,
  • Jinguan Lin,
  • Qianjin Liao,
  • Yaqian Han,
  • Yujuan Zhou

摘要

Lactate is a crucial product of cancer metabolism, creating an acidic environment that supports cancer growth and acts as a substrate for lactylation. Lactylation, a newly discovered epigenetic modification, plays a vital role in cancer cell signaling, metabolic reprogramming, immune response, and other functions. This review explores the regulation of lactylation, summarizes recent research on its role in cancers, and highlights its application in cancer drug resistance and immunotherapy. These insights aim to provide new avenues for targeting lactylation in cancer therapy.