Acute exposure of microwave impairs attention process by activating microglial inflammation

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发表日期：

2024年1月4日

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Shaofei Jiang,
Yingping Ma,
Yuan Shi,
Yong Zou,
Zhenqi Yang,
Weijia Zhi,
Zhe Zhao,
Wei Shen,
Liping Chen,
Yan Wu,
Lifeng Wang,
Xiangjun Hu,
Haitao Wu

摘要

Background

Attention provides the foundation for cognitions, which was shown to be affected by microwave (MW) radiation. With the ubiquitous of microwaves, public concerns regarding the impact of MW radiation on attention has hence been increased. Our study aims to investigate the potential effect and mechanism of acute microwave exposure on attention.

Results

We identified obvious impairment of attention in mice by the five-choice serial reaction time (5-CSRT) task. Proteomic analysis of the cerebrospinal fluid (CSF) revealed neuroinflammation and microglial activation potentially due to acute MW exposure. Moreover, biochemical analysis further confirmed microglial activation in the prefrontal cortex (PFC) of mice subjected to acute MW exposure. Finally, minocycline, a commercially available anti-inflammatory compound, attenuated neuroinflammation, inhibited the upregulation of N-methyl-D-aspartic acid receptor (NMDAR) including NR2A and NR2B, and also accelerated the attentional recovery after MW exposure.

Conclusions

We believe that microglial activation and NMDAR upregulation likely contribute to inattention induced by acute MW exposure, and we found that minocycline may be effective in preventing such process.