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<p>The widespread emergence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has become a major public health concern worldwide, highlighting the urgent need for innovative antimicrobial agents with specific efficacy against MRSA. In this study, cryptotanshinone effectively inhibited the growth of <i>S. aureus</i> strains, including ATCC 29,213, USA 300, and ATCC 43,300. Increasing levels of reactive oxygen species induced oxidative stress, changed membrane potential, increased membrane permeability, and dramatically decreased intracellular adenosine triphosphate (ATP) levels. In addition, cryptotanshinone showed little toxic effect on cell lines and was not significantly hemolytic at 10–200 µM. In a mouse model of MRSA skin infection, cryptotanshinone substantially lowered bacterial counts and lessened tissue injury. The histopathological examination revealed that the cryptotanshinone-treated group showed less damage than the vehicle group, which indicates milder necrosis and inflammatory cell infiltration. Collectively, these findings suggest that cryptotanshinone exhibits notable anti-MRSA activity with a favourable safety profile, warranting further investigation.</p>

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Cryptotanshinone targets the bacterial membrane and inhibits methicillin-resistant Staphylococcus aureus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月17日

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  • Qingyu Liu,
  • Yongxue Tang,
  • Siyu Wang,
  • Chao Wang,
  • Ping Tan,
  • Xiaomei Wang,
  • Hui Zhou,
  • Huibin Zhu,
  • Xiaobing Xie,
  • Xingwang Ning

摘要

The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a major public health concern worldwide, highlighting the urgent need for innovative antimicrobial agents with specific efficacy against MRSA. In this study, cryptotanshinone effectively inhibited the growth of S. aureus strains, including ATCC 29,213, USA 300, and ATCC 43,300. Increasing levels of reactive oxygen species induced oxidative stress, changed membrane potential, increased membrane permeability, and dramatically decreased intracellular adenosine triphosphate (ATP) levels. In addition, cryptotanshinone showed little toxic effect on cell lines and was not significantly hemolytic at 10–200 µM. In a mouse model of MRSA skin infection, cryptotanshinone substantially lowered bacterial counts and lessened tissue injury. The histopathological examination revealed that the cryptotanshinone-treated group showed less damage than the vehicle group, which indicates milder necrosis and inflammatory cell infiltration. Collectively, these findings suggest that cryptotanshinone exhibits notable anti-MRSA activity with a favourable safety profile, warranting further investigation.