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<p>The research investigated the effects of that magnetic nanoparticles coated with the plant-based flavonoid quercetin have on the growth of <i>Staphylococcus aureus</i>. The synthesis of magnetic nanoparticles proceeded through co-precipitation and further involved quercetin coating using a dextran stabilizer. A combined product of these materials received the chemical name Fe<sub>3</sub>O<sub>4</sub>@Dex-QT. The study included multiple analytical tests such as FTIR (Fourier Transform Infrared Spectroscopy), FE-SEM (Field Emission Scanning Electron Microscopy), EDS (Energy-Dispersive X-Ray Spectroscopy) and XRD (X-ray diffraction) together with cellular and molecular assays. Biofilm detection experiments showed that 95% of studied microorganisms had moderate-to-strong biofilm formation abilities. The examined strains that formed biofilms exhibited complete biofilm inhibition at a minimum concentration of 512&#xa0;μg/mL.<!--Query ID="Q1" Text="Please confirm if the author names are presented accurately and in the correct sequence (given name, middle nameinitial, family name). Author 2 Given name: [Masoumeh Pakpour] Last name [Roudsari], Author 3 Given name: [Seyyed Mahdi] Last name [ZiaZiabari]. Also, kindly confirm the details in the metadata are correct." Resolved="yes"--> Post-treatment with Fe<sub>3</sub>O<sub>4</sub>@Dex-QT nanoparticles, the <i>Coa</i> and <i>Hla</i> genes were expressed at 30 and 20% levels respectively, as determined through RT-PCR analysis. The research uncovered that Fe<sub>3</sub>O<sub>4</sub>@Dex-QT nanoparticles demonstrate successful antibacterial properties against <i>S. aureus</i> strains, making them viable for substituting conventional antibiotics.</p> Graphical abstract <p></p>

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Quercetin-conjugated magnetic nanoparticles inhibit Staphylococcus aureus growth and biofilm formation via downregulation of Coa and Hla genes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月15日

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  • Alireza Habibi,
  • Masoumeh Pakpour Roudsari,
  • Seyyed Mahdi ZiaZiabari

摘要

The research investigated the effects of that magnetic nanoparticles coated with the plant-based flavonoid quercetin have on the growth of Staphylococcus aureus. The synthesis of magnetic nanoparticles proceeded through co-precipitation and further involved quercetin coating using a dextran stabilizer. A combined product of these materials received the chemical name Fe3O4@Dex-QT. The study included multiple analytical tests such as FTIR (Fourier Transform Infrared Spectroscopy), FE-SEM (Field Emission Scanning Electron Microscopy), EDS (Energy-Dispersive X-Ray Spectroscopy) and XRD (X-ray diffraction) together with cellular and molecular assays. Biofilm detection experiments showed that 95% of studied microorganisms had moderate-to-strong biofilm formation abilities. The examined strains that formed biofilms exhibited complete biofilm inhibition at a minimum concentration of 512 μg/mL. Post-treatment with Fe3O4@Dex-QT nanoparticles, the Coa and Hla genes were expressed at 30 and 20% levels respectively, as determined through RT-PCR analysis. The research uncovered that Fe3O4@Dex-QT nanoparticles demonstrate successful antibacterial properties against S. aureus strains, making them viable for substituting conventional antibiotics.

Graphical abstract