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<p>This study aimed to evaluate the antidiabetic, dermatoprotective, and antibacterial properties of <i>Mentha pulegium</i> L. essential oil (MPEO), harvested in Ouezzane, northwest Morocco. Gas chromatography-mass spectrometry (GC–MS) analysis identified pulegone (41.0%) and menthone (21.2%) as the major constituents. The antibacterial activity was assessed using the micro-broth dilution method, while antidiabetic and dermatoprotective effects were evaluated via in vitro inhibition of α-amylase, α-glucosidase, tyrosinase, and elastase. Additionally, molecular docking was used to assess interactions between key enzymes and major compounds. Both menthone and pulegone exhibited strong antibacterial effects against <i>Staphylococcus aureus</i> and <i>Listeria monocytogenes</i>, with MIC and MBC values ranging from 0.125 to 0.25&#xa0;µg/mL. Remarkably, menthone and pulegone demonstrated MIC = MBC = 0.125&#xa0;µg/mL against <i>S. aureus</i> and <i>L. monocytogenes</i>, respectively. In antidiabetic assays, all tested compounds outperformed acarbose. Menthone showed the best inhibition with IC₅₀ values of 149.32 ± 4.16 and 108.39 ± 4.08&#xa0;μg/mL for α-amylase and α-glucosidase, respectively. MPEO also displayed potent dermatoprotective activity, with IC₅₀ values of 56.23 ± 2.24&#xa0;μg/mL (tyrosinase) and 90.36 ± 2.26&#xa0;μg/mL (elastase), compared to quercetin. In silico analysis confirmed strong binding affinities of pulegone and menthone to target enzymes involved in glucose regulation.<!--Query ID="Q1" Text="Please confirm if the author names are presented accurately and in the correct sequence (given name, middle nameinitial, family name). Author 1 Given name: [Nasreddine El] Last name [Omari], Author 4 Given name: [Naoual El] Last name [Menyiy], Author 4 Given name: [Long Chiau] Last name [Ming]. Also, kindly confirm the details in the metadata are correct." Resolved="yes"--> These findings highlight MPEO as a promising natural source of bioactive compounds with antibacterial, antidiabetic, and dermatoprotective properties, supporting its potential use in pharmaceutical and therapeutic applications.</p>

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Expediting multiple biological properties of main bioactive compounds of Mentha pulegium L

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月14日

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  • Nasreddine El Omari,
  • Oumayma Aguerd,
  • Abdelaali Balahbib,
  • Naoual El Menyiy,
  • Mohammed Amanullah,
  • Jactty Chew,
  • Long Chiau Ming,
  • Abdelhakim Bouyahya

摘要

This study aimed to evaluate the antidiabetic, dermatoprotective, and antibacterial properties of Mentha pulegium L. essential oil (MPEO), harvested in Ouezzane, northwest Morocco. Gas chromatography-mass spectrometry (GC–MS) analysis identified pulegone (41.0%) and menthone (21.2%) as the major constituents. The antibacterial activity was assessed using the micro-broth dilution method, while antidiabetic and dermatoprotective effects were evaluated via in vitro inhibition of α-amylase, α-glucosidase, tyrosinase, and elastase. Additionally, molecular docking was used to assess interactions between key enzymes and major compounds. Both menthone and pulegone exhibited strong antibacterial effects against Staphylococcus aureus and Listeria monocytogenes, with MIC and MBC values ranging from 0.125 to 0.25 µg/mL. Remarkably, menthone and pulegone demonstrated MIC = MBC = 0.125 µg/mL against S. aureus and L. monocytogenes, respectively. In antidiabetic assays, all tested compounds outperformed acarbose. Menthone showed the best inhibition with IC₅₀ values of 149.32 ± 4.16 and 108.39 ± 4.08 μg/mL for α-amylase and α-glucosidase, respectively. MPEO also displayed potent dermatoprotective activity, with IC₅₀ values of 56.23 ± 2.24 μg/mL (tyrosinase) and 90.36 ± 2.26 μg/mL (elastase), compared to quercetin. In silico analysis confirmed strong binding affinities of pulegone and menthone to target enzymes involved in glucose regulation. These findings highlight MPEO as a promising natural source of bioactive compounds with antibacterial, antidiabetic, and dermatoprotective properties, supporting its potential use in pharmaceutical and therapeutic applications.