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<p>Feline panleukopenia virus (FPV) poses a significant threat to carnivores worldwide, with increasing documentation of spillover infections in endangered species, including the giant panda (<i>Ailuropoda melanoleuca</i>). Despite the presence of serological evidence indicating historical exposure, contemporary data concerning the prevalence of FPV and the associated risk factors in giant pandas remains limited. This study conducted a comprehensive seroepidemiological survey of 136 giant pandas, representing 262 serum samples, from the Chengdu Research Base of Giant Panda Breeding between 2015 and 2023. The overall seroprevalence of FPV antibodies was 56.87% (149/262, 95% CI 0.51–0.63), with consistently high levels observed across years. Multivariate analysis identified young age and the summer season as protective factors, likely due to maternal-derived antibodies and environmentally mediated reduction in viral persistence, respectively. Although not statistically significant, a transfer history showed a trend toward elevated risk (OR &gt; 1), suggesting that it may still represent a potential risk factor. It is important to note that current vaccination protocols appear to be inadequate in eliciting robust immune responses, thereby underscoring the necessity for the development of tailored vaccines. These findings emphasize the persistent and widespread circulation of FPV in captive giant pandas and advocate for seasonally targeted biosecurity measures, rationalized animal transfer protocols, and enhanced immunization strategies to mitigate infection risks in this vulnerable species.</p>

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Seroprevalence and associated risk factors for feline panleukopenia virus infection among managed giant pandas in China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月15日

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  • Yunli Li,
  • Renyong Jia,
  • Hongwen Zhang,
  • Xin Chen,
  • Jianhong Zeng,
  • Jingchao Lan,
  • Chanjuan Yue,
  • Dongsheng Zhang,
  • Wenjun Huang,
  • Wanjing Yang,
  • Xueyang Fan,
  • Xianzhu Xia,
  • Rong Hou,
  • Na Feng,
  • Songrui Liu

摘要

Feline panleukopenia virus (FPV) poses a significant threat to carnivores worldwide, with increasing documentation of spillover infections in endangered species, including the giant panda (Ailuropoda melanoleuca). Despite the presence of serological evidence indicating historical exposure, contemporary data concerning the prevalence of FPV and the associated risk factors in giant pandas remains limited. This study conducted a comprehensive seroepidemiological survey of 136 giant pandas, representing 262 serum samples, from the Chengdu Research Base of Giant Panda Breeding between 2015 and 2023. The overall seroprevalence of FPV antibodies was 56.87% (149/262, 95% CI 0.51–0.63), with consistently high levels observed across years. Multivariate analysis identified young age and the summer season as protective factors, likely due to maternal-derived antibodies and environmentally mediated reduction in viral persistence, respectively. Although not statistically significant, a transfer history showed a trend toward elevated risk (OR > 1), suggesting that it may still represent a potential risk factor. It is important to note that current vaccination protocols appear to be inadequate in eliciting robust immune responses, thereby underscoring the necessity for the development of tailored vaccines. These findings emphasize the persistent and widespread circulation of FPV in captive giant pandas and advocate for seasonally targeted biosecurity measures, rationalized animal transfer protocols, and enhanced immunization strategies to mitigate infection risks in this vulnerable species.