Scholarlink

<p><i>Streptococcus suis</i> (<i>S</i>. <i>suis</i>) is an important invasive porcine pathogen. Here, we describe a new lymph node infection model where 7 × 10<sup>3</sup>&#xa0;CFU <i>S</i>. <i>suis</i> serotype 2 were injected in the left cervical lymph node. In total, seven out of eight 5-week-old piglets developed clinical signs of disease. In all infected pigs, <i>S</i>. <i>suis</i> was reisolated from the infected lymph node and one or more additional sites. Immunohistochemically, <i>S</i>. <i>suis</i> antigen was located predominantly in the sinus. The results suggest that <i>S</i>. <i>suis</i> easily disseminates after lymph node infection and that the interaction with cells of the mononuclear phagocytic system, primarily in the lymph node sinus, plays an important role in host cell–pathogen interaction.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A new lymph node infection model for Streptococcus suis serotype 2 in pigs

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月2日

查看全文
  • Annika Katharina Breitfelder,
  • Tatjana Sattler,
  • Johannes Kauffold,
  • Sarah Pfetzing,
  • Anna Majcher,
  • Reiner Ulrich,
  • Uwe Müller,
  • Sophie Öhlmann,
  • Karoline Rieckmann,
  • Christoph Georg Baums

摘要

Streptococcus suis (S. suis) is an important invasive porcine pathogen. Here, we describe a new lymph node infection model where 7 × 103 CFU S. suis serotype 2 were injected in the left cervical lymph node. In total, seven out of eight 5-week-old piglets developed clinical signs of disease. In all infected pigs, S. suis was reisolated from the infected lymph node and one or more additional sites. Immunohistochemically, S. suis antigen was located predominantly in the sinus. The results suggest that S. suis easily disseminates after lymph node infection and that the interaction with cells of the mononuclear phagocytic system, primarily in the lymph node sinus, plays an important role in host cell–pathogen interaction.