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Background <p><sup>11</sup>C-acetate positron emission tomography (PET) enables simultaneous quantification of myocardial blood flow (MBF) and oxidative metabolism; however, sex-specific normative data under vasodilator stress remain insufficiently defined. We aimed to characterize these parameters in healthy individuals.</p> Results <p>Eighteen healthy individuals (9 males and 9 females, age/sex-matched; median age 43 years [range 34–65]) with normal echocardiography and no underlying cardiovascular disease underwent one-day rest-stress dynamic <sup>11</sup>C-acetate PET with adenosine. Median stress MBF was 2.73 (2.24–3.11) mL/min/g and rest MBF 0.99 (0.82–1.14) mL/min/g. Stress kmono was 0.074 (0.063–0.082)/min, and rest kmono was 0.061 (0.050–0.068)/min. External cardiac work, total myocardial oxygen consumption (MVO₂), and MEE were 4.24 (3.75–5.54) × 10⁵ mL·mmHg/min, 16.5 (14.9–20.9) mL/min, and 17.7% (14.0–24.2%), respectively. Compared to males, females exhibited significantly higher corrected rest MBF (1.14 vs. 0.96 mL/min/g, <i>p</i> = 0.032), stress kmono (0.078 vs. 0.070 /min, <i>p</i> = 0.005), and total MVO₂ (17.6 vs. 15.5 mL/min, <i>p</i> = 0.003). Despite similar external cardiac work, myocardial external efficiency was significantly lower in females (15.5% vs. 20.3%, <i>p</i> = 0.009). MBF and oxidative metabolism were positively correlated in both sexes.</p> Conclusions <p>This study assesses reference ranges and demonstrates significant sex-based differences in myocardial perfusion and oxidative metabolism using vasodilatory stress <sup>11</sup>C-acetate PET. These findings provide a valuable physiological framework for assessing perfusion-metabolism abnormalities in clinical practice.</p>

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Myocardial perfusion and oxidative metabolism in healthy subjects: sex-specific insights from vasodilatory stress 11C-acetate PET

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月2日

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  • Sang-Geon Cho,
  • Hyung Yoon Kim,
  • Ki Seong Park,
  • Jahae Kim,
  • Jang Bae Moon,
  • Nuri Lee,
  • Hyukjin Park,
  • Jae Yeong Cho,
  • Hyun Ju Yoon,
  • Youngkeun Ahn,
  • Joon-Hyung Doh,
  • Eun-Seok Shin,
  • Kye Hun Kim,
  • Ho-Chun Song

摘要

Background

11C-acetate positron emission tomography (PET) enables simultaneous quantification of myocardial blood flow (MBF) and oxidative metabolism; however, sex-specific normative data under vasodilator stress remain insufficiently defined. We aimed to characterize these parameters in healthy individuals.

Results

Eighteen healthy individuals (9 males and 9 females, age/sex-matched; median age 43 years [range 34–65]) with normal echocardiography and no underlying cardiovascular disease underwent one-day rest-stress dynamic 11C-acetate PET with adenosine. Median stress MBF was 2.73 (2.24–3.11) mL/min/g and rest MBF 0.99 (0.82–1.14) mL/min/g. Stress kmono was 0.074 (0.063–0.082)/min, and rest kmono was 0.061 (0.050–0.068)/min. External cardiac work, total myocardial oxygen consumption (MVO₂), and MEE were 4.24 (3.75–5.54) × 10⁵ mL·mmHg/min, 16.5 (14.9–20.9) mL/min, and 17.7% (14.0–24.2%), respectively. Compared to males, females exhibited significantly higher corrected rest MBF (1.14 vs. 0.96 mL/min/g, p = 0.032), stress kmono (0.078 vs. 0.070 /min, p = 0.005), and total MVO₂ (17.6 vs. 15.5 mL/min, p = 0.003). Despite similar external cardiac work, myocardial external efficiency was significantly lower in females (15.5% vs. 20.3%, p = 0.009). MBF and oxidative metabolism were positively correlated in both sexes.

Conclusions

This study assesses reference ranges and demonstrates significant sex-based differences in myocardial perfusion and oxidative metabolism using vasodilatory stress 11C-acetate PET. These findings provide a valuable physiological framework for assessing perfusion-metabolism abnormalities in clinical practice.