Scholarlink

Background <p>[<sup>99m</sup>Tc]Tc-MIBI is a conventional myocardial perfusion radiotracer, and is predominantly taken up by mitochondria in a manner dependent on mitochondrial membrane potential. This study aimed to repurpose [<sup>99m</sup>Tc]Tc-MIBI for functional renal imaging to evaluate mitochondrial dysfunction in chronic kidney disease (CKD).</p> Results <p>A total of 11 patients with newly diagnosed CKD and 27 matched healthy volunteers underwent [99mTc]Tc-MIBI dynamic renal scans and SPECT/CT. Quantitative analyses of the left kidneys assessed time-activity curves, percentage of renal uptake, and standardized uptake values (SUV). Renal mitochondrial content in CKD patients was evaluated using immunohistochemistry of kidney biopsy samples. CKD patients had comparable eGFR to healthy volunteers but exhibited significantly lower renal [<sup>99m</sup>Tc]Tc-MIBI uptake percentage on dynamic scan and decreased SUV on SPECT/CT. A positive correlation was observed between mean SUV and renal mitochondrial content in CKD patients. Mean SUV was identified as an independent predictor of CKD (odds ratio 0.2, <i>P</i> = 0.037), demonstrating high diagnostic accuracy (AUC = 0.886), whereas conventional biomarkers had limited predictive value.</p> Conclusions <p>[<sup>99m</sup>Tc]Tc-MIBI kidney SPECT/CT effectively detected renal mitochondrial dysfunction in patients with CKD, suggests its potential as a noninvasive imaging biomarker. SUV may serve as a quantitative parameter for assessing renal mitochondrial dysfunction.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Imaging renal mitochondrial dysfunction in chronic kidney disease: a repurposed role for [99mTc]Tc-MIBI SPECT/CT

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月2日

查看全文
  • Soo Bin Park,
  • Chae Hong Lim,
  • So-Young Jin,
  • Yon Hee Kim,
  • Haekyung Lee,
  • Hyoungnae Kim,
  • Hyunjin Noh,
  • Jin Seok Jeon,
  • Soon Hyo Kwon

摘要

Background

[99mTc]Tc-MIBI is a conventional myocardial perfusion radiotracer, and is predominantly taken up by mitochondria in a manner dependent on mitochondrial membrane potential. This study aimed to repurpose [99mTc]Tc-MIBI for functional renal imaging to evaluate mitochondrial dysfunction in chronic kidney disease (CKD).

Results

A total of 11 patients with newly diagnosed CKD and 27 matched healthy volunteers underwent [99mTc]Tc-MIBI dynamic renal scans and SPECT/CT. Quantitative analyses of the left kidneys assessed time-activity curves, percentage of renal uptake, and standardized uptake values (SUV). Renal mitochondrial content in CKD patients was evaluated using immunohistochemistry of kidney biopsy samples. CKD patients had comparable eGFR to healthy volunteers but exhibited significantly lower renal [99mTc]Tc-MIBI uptake percentage on dynamic scan and decreased SUV on SPECT/CT. A positive correlation was observed between mean SUV and renal mitochondrial content in CKD patients. Mean SUV was identified as an independent predictor of CKD (odds ratio 0.2, P = 0.037), demonstrating high diagnostic accuracy (AUC = 0.886), whereas conventional biomarkers had limited predictive value.

Conclusions

[99mTc]Tc-MIBI kidney SPECT/CT effectively detected renal mitochondrial dysfunction in patients with CKD, suggests its potential as a noninvasive imaging biomarker. SUV may serve as a quantitative parameter for assessing renal mitochondrial dysfunction.