FAIR Data Cube, a FAIR data infrastructure for integrated multi-omics data analysis

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2024年12月28日

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Xiaofeng Liao,
Thomas H.A. Ederveen,
Anna Niehues,
Casper de Visser,
Junda Huang,
Firdaws Badmus,
Cenna Doornbos,
Yuliia Orlova,
Purva Kulkarni,
K. Joeri van der Velde,
Morris A. Swertz,
Martin Brandt,
Alain J. van Gool,
Peter A. C. ’t Hoen

摘要

Motivation

We are witnessing an enormous growth in the amount of molecular profiling (-omics) data. The integration of multi-omics data is challenging. Moreover, human multi-omics data may be privacy-sensitive and can be misused to de-anonymize and (re-)identify individuals. Hence, most biomedical data is kept in secure and protected silos. Therefore, it remains a challenge to re-use these data without infringing the privacy of the individuals from which the data were derived. Federated analysis of Findable, Accessible, Interoperable, and Reusable (FAIR) data is a privacy-preserving solution to make optimal use of these multi-omics data and transform them into actionable knowledge.

Results

The Netherlands X-omics Initiative is a National Roadmap Large-Scale Research Infrastructure aiming for efficient integration of data generated within X-omics and external datasets. To facilitate this, we developed the FAIR Data Cube (FDCube), which adopts and applies the FAIR principles and helps researchers to create FAIR data and metadata, to facilitate re-use of their data, and to make their data analysis workflows transparent, and in the meantime ensure data security and privacy.