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<p>Protein solubility prediction holds significant importance in the fields of biotechnology and medicine. With the continual advancements of computational and experimental techniques such as protein design, enzyme mining, and directed evolution, accurate prediction of native and mutant protein solubility has become a key step in accelerating the development of functional proteins. In this study, we extracted physicochemical properties and co-evolutionary features from protein sequences, and further incorporated graph-based protein representations along with surface features as inputs for solubility prediction. Building upon these features, we developed two models, ProSolNet and ProSolNet<sub>Mut</sub>. ProSolNet predicts whether a protein is soluble, while ProSolNet<sub>Mut</sub> predicts solubility changes induced by mutations. Compared with state-of-the-art models, both models achieved higher accuracy in their respective tasks. In addition, we investigated the underlying mechanisms and application potential of the models through interpretability analysis.&#xa0;</p>

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Integrating multimodal features with deep learning for protein solubility prediction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Zechen Wang,
  • Lai Heng Tan,
  • Liangzhen Zheng,
  • Jagath C. Rajapakse,
  • Yuguang Mu

摘要

Protein solubility prediction holds significant importance in the fields of biotechnology and medicine. With the continual advancements of computational and experimental techniques such as protein design, enzyme mining, and directed evolution, accurate prediction of native and mutant protein solubility has become a key step in accelerating the development of functional proteins. In this study, we extracted physicochemical properties and co-evolutionary features from protein sequences, and further incorporated graph-based protein representations along with surface features as inputs for solubility prediction. Building upon these features, we developed two models, ProSolNet and ProSolNetMut. ProSolNet predicts whether a protein is soluble, while ProSolNetMut predicts solubility changes induced by mutations. Compared with state-of-the-art models, both models achieved higher accuracy in their respective tasks. In addition, we investigated the underlying mechanisms and application potential of the models through interpretability analysis.