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<p>Alternative splicing (AS) significantly enhances transcriptomic diversity, and its dysregulation is implicated in numerous human diseases. However, no public database systematically compiles sex-related AS events across human tissues. We developed SASdb (<a href="http://www.gdbioinfo.top/sasdb">http://www.gdbioinfo.top/sasdb</a>), a comprehensive database contains 2,951,059 AS events and 46,418 sex-biased alternative splicing (SAS) events, covering 22 human tissues. SASdb reveals extensive sex-specific splicing patterns, offering new insights into molecular sex differences. A case study on NSCLC-specific SAS events, absent in healthy tissues, highlights their enrichment in cancer-related pathways like autophagy, GPI-anchor biosynthesis, and AMPK/mTOR signaling. SASdb’s intuitive visualization supports research in sex biology and precision medicine.</p>

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SASdb: a comprehensive database for sex-biased alternative splicing profiles in human tissues

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月26日

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  • Xi Chen,
  • Yueqi Lu,
  • You Duan,
  • Yongfeng Bai,
  • Weidong Ye,
  • Sijia Chen,
  • Hang Zhou,
  • Heng Xu,
  • Le Xu,
  • Cheng Guo

摘要

Alternative splicing (AS) significantly enhances transcriptomic diversity, and its dysregulation is implicated in numerous human diseases. However, no public database systematically compiles sex-related AS events across human tissues. We developed SASdb (http://www.gdbioinfo.top/sasdb), a comprehensive database contains 2,951,059 AS events and 46,418 sex-biased alternative splicing (SAS) events, covering 22 human tissues. SASdb reveals extensive sex-specific splicing patterns, offering new insights into molecular sex differences. A case study on NSCLC-specific SAS events, absent in healthy tissues, highlights their enrichment in cancer-related pathways like autophagy, GPI-anchor biosynthesis, and AMPK/mTOR signaling. SASdb’s intuitive visualization supports research in sex biology and precision medicine.