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<p>T cell exhaustion is a hallmark of failure to control cancer and chronic infection. In hematological malignancies, T cell exhaustion not only relates to disease progression but also impacts the outcome of hematopoietic stem cell transplantation (HSCT), which may be due to a low graft-versus-leukemia (GVL) effect and a low anti-virus infection capacity. However, a deeper mechanistic understanding of the impact of T cell exhaustion in HSCT remains to be characterized. In this review, we summarize the characteristics of T cell exhaustion, functional alterations in T cells post-transplantation, the role of T cell exhaustion in post-transplant complications, and related therapeutic strategies.</p>

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The impact of T cell exhaustion in hematopoietic stem cell transplantation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月28日

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  • Yue Li,
  • Huidong Guo,
  • Yikai Zhang,
  • Jie Chen,
  • Liye Zhong,
  • Xiaojun Huang,
  • Yangqiu Li

摘要

T cell exhaustion is a hallmark of failure to control cancer and chronic infection. In hematological malignancies, T cell exhaustion not only relates to disease progression but also impacts the outcome of hematopoietic stem cell transplantation (HSCT), which may be due to a low graft-versus-leukemia (GVL) effect and a low anti-virus infection capacity. However, a deeper mechanistic understanding of the impact of T cell exhaustion in HSCT remains to be characterized. In this review, we summarize the characteristics of T cell exhaustion, functional alterations in T cells post-transplantation, the role of T cell exhaustion in post-transplant complications, and related therapeutic strategies.