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<p>Cholesterol, a key steroid in cell membranes and organelles, is vital for processes like migration and apoptosis, regulated by biosynthesis, uptake, and esterification. Its metabolism significantly impacts stem cell fate via pathways like AKT/FOXO1 and Notch, influencing proliferation, differentiation, and migration. Thus, cholesterol emerges as a promising therapeutic target. This review aims to shed light on the impact of cholesterol metabolism on stem cells and explores cholesterol-targeting drugs’ potential in regenerative medicine. Our purpose is to elucidate cholesterol’s role in stem cell function and guide therapeutic development.</p> Graphical abstract <p></p>

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Cholesterol metabolism on stem cell fate determination: a frontier horizon

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月14日

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  • Boyang Xu,
  • Ling Li,
  • Qian Wei,
  • Yuli Wang,
  • He Huang,
  • Tao Pang,
  • Zhijian Wei,
  • Guoqing Zheng,
  • Yue Li

摘要

Cholesterol, a key steroid in cell membranes and organelles, is vital for processes like migration and apoptosis, regulated by biosynthesis, uptake, and esterification. Its metabolism significantly impacts stem cell fate via pathways like AKT/FOXO1 and Notch, influencing proliferation, differentiation, and migration. Thus, cholesterol emerges as a promising therapeutic target. This review aims to shed light on the impact of cholesterol metabolism on stem cells and explores cholesterol-targeting drugs’ potential in regenerative medicine. Our purpose is to elucidate cholesterol’s role in stem cell function and guide therapeutic development.

Graphical abstract