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Background <p>Hodgkin lymphoma is a malignant lymphoid neoplasm that most commonly originates in lymph nodes, particularly within the cervical, mediastinal, and axillary regions. Extranodal involvement is relatively uncommon, and primary nasopharyngeal Hodgkin lymphoma defines a rare clinical phenomenon. Diagnosis may be delayed because its clinical presentation resembles more common nasopharyngeal conditions.</p> Case presentation <p>A 51-year-old Palestinian woman presented with progressive nasal obstruction and snoring. Endoscopic examination revealed a mass in the nasopharynx. Histopathological analysis confirmed lymphocyte-rich classical Hodgkin lymphoma, staged as IIA. The patient was treated with four cycles of ABVD chemotherapy followed by involved-site radiotherapy using CT simulation with a total dose of 30.6&#xa0;Gy delivered in 17 fractions, resulting in complete resolution of the lesion. At 12&#xa0;months of follow-up, the patient remained disease-free with full clinical recovery.</p> Conclusion <p>This case highlights the diagnostic challenges posed by rare extranodal presentations of Hodgkin lymphoma and illustrates the value of maintaining a broad differential diagnosis and performing timely histopathological evaluation in patients with persistent nasal symptoms.</p>

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Nasopharyngeal classical Hodgkin lymphoma: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月8日

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  • Suhaib Eid,
  • Somaya Al Kiswani,
  • Hossam Salameh,
  • Nidal Almasri,
  • Nooreddin Saifi,
  • Omar Sawafta

摘要

Background

Hodgkin lymphoma is a malignant lymphoid neoplasm that most commonly originates in lymph nodes, particularly within the cervical, mediastinal, and axillary regions. Extranodal involvement is relatively uncommon, and primary nasopharyngeal Hodgkin lymphoma defines a rare clinical phenomenon. Diagnosis may be delayed because its clinical presentation resembles more common nasopharyngeal conditions.

Case presentation

A 51-year-old Palestinian woman presented with progressive nasal obstruction and snoring. Endoscopic examination revealed a mass in the nasopharynx. Histopathological analysis confirmed lymphocyte-rich classical Hodgkin lymphoma, staged as IIA. The patient was treated with four cycles of ABVD chemotherapy followed by involved-site radiotherapy using CT simulation with a total dose of 30.6 Gy delivered in 17 fractions, resulting in complete resolution of the lesion. At 12 months of follow-up, the patient remained disease-free with full clinical recovery.

Conclusion

This case highlights the diagnostic challenges posed by rare extranodal presentations of Hodgkin lymphoma and illustrates the value of maintaining a broad differential diagnosis and performing timely histopathological evaluation in patients with persistent nasal symptoms.