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Background <p>Chronic idiopathic urticaria is a challenging condition that may require advanced therapies, such as omalizumab. Its association with malignancy, particularly papillary thyroid carcinoma, remains unclear and is rarely reported.</p> Case presentation <p>A 31-year-old Omani woman, with treatment-resistant idiopathic chronic urticaria requiring omalizumab for symptom control was subsequently diagnosed with papillary thyroid carcinoma. The patient underwent total thyroidectomy, after which she experienced partial remission of urticaria symptoms, including the longest symptom-free interval since disease onset.</p> Conclusions <p>This case highlights a potential association between papillary thyroid carcinoma and chronic idiopathic urticaria, suggesting that evaluation for underlying malignancy may be considered in refractory cases.</p>

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Treatment-resistant chronic urticaria associated with papillary thyroid carcinoma: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月27日

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  • Muzna Al Farsi,
  • Maisa Hamed Al Kiyumi

摘要

Background

Chronic idiopathic urticaria is a challenging condition that may require advanced therapies, such as omalizumab. Its association with malignancy, particularly papillary thyroid carcinoma, remains unclear and is rarely reported.

Case presentation

A 31-year-old Omani woman, with treatment-resistant idiopathic chronic urticaria requiring omalizumab for symptom control was subsequently diagnosed with papillary thyroid carcinoma. The patient underwent total thyroidectomy, after which she experienced partial remission of urticaria symptoms, including the longest symptom-free interval since disease onset.

Conclusions

This case highlights a potential association between papillary thyroid carcinoma and chronic idiopathic urticaria, suggesting that evaluation for underlying malignancy may be considered in refractory cases.