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Background <p>Functional gonadotropic adenoma is a rare pituitary adenoma. Only a few cases have been reported.</p> Case presentation <p>Herein, we describe the case of a 30-year-old Chinese woman with functional gonadotroph adenomas (FGAs) with relative hyperprolactinemia and no obvious neurologic signs. Ovarian hyperstimulation due to a follicle-stimulating hormone (FSH)-secreting adenoma was observed after treatment with a gonadotropin-releasing hormone analogue (GnRH-a). The patient was successfully treated through pituitary adenomectomy and experienced a successful pregnancy after <i>in vitro</i> fertilization (IVF).</p> Conclusion <p>Our report suggests that a patient showing ovarian hyperstimulation related to an FSH-secreting adenoma may present with high PRL and estradiol levels and indicates that transsphenoidal surgery should be the first choice for treatment.</p>

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In vitro fertilization-frozen embryo transfer in a patient with gonadotroph adenoma: Exacerbation of ovarian hyperstimulation by triptorelin: a case report

  • 期刊论文

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  • 发表日期：

    2026年6月25日

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  • Feifei Lu,
  • Manlin Xu,
  • Xiaoyue Shen,
  • Na Kong,
  • Jingyu Liu,
  • Yue Jiang

摘要

Background

Functional gonadotropic adenoma is a rare pituitary adenoma. Only a few cases have been reported.

Case presentation

Herein, we describe the case of a 30-year-old Chinese woman with functional gonadotroph adenomas (FGAs) with relative hyperprolactinemia and no obvious neurologic signs. Ovarian hyperstimulation due to a follicle-stimulating hormone (FSH)-secreting adenoma was observed after treatment with a gonadotropin-releasing hormone analogue (GnRH-a). The patient was successfully treated through pituitary adenomectomy and experienced a successful pregnancy after in vitro fertilization (IVF).

Conclusion

Our report suggests that a patient showing ovarian hyperstimulation related to an FSH-secreting adenoma may present with high PRL and estradiol levels and indicates that transsphenoidal surgery should be the first choice for treatment.