Scholarlink

Background <p>Castleman disease (CD) is a rare lymphoproliferative disorder of unclear etiology, often presenting as an asymptomatic, incidentally detected mass. The predominant pathological variants include hyaline vascular, plasma cell, and mixed types. Clinically, CD is classified into unicentric (UCD) and multicentric (MCD) forms.</p> Case presentation <p>Here we report the case of a 34-year-old Indian female with vague left-sided abdominal pain and bilateral lower limb pain, in whom contrast-enhanced CT revealed an incidental well-defined 5.7 × 3.8 × 3.8&#xa0;cm mass in the gastrohepatic space, initially suggestive of a pancreatic neuroendocrine tumor or gastrointestinal stromal tumor. However, endoscopic ultrasound-guided biopsy indicated a lymphoproliferative neoplasm. Given the discordant imaging and biopsy findings, surgical resection of the mass was undertaken, and the final histopathology confirmed unicentric Castleman disease. No adjuvant therapy was required, and the patient remains disease-free at 2&#xa0;years of follow-up.</p> Conclusion <p>This case underscores the favorable prognosis of UCD—complete surgical resection is associated with near 100% long-term survival—and the importance of differentiating such lesions from other retroperitoneal tumors, which are usually malignant. A thorough preoperative evaluation, including an excisional lymph node biopsy or intraoperative frozen section, is recommended to establish the diagnosis and guide management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Retroperitoneal Castleman disease masquerading as a pancreatic neoplasm: a case report and review of the literature

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月7日

查看全文
  • Sanket Solanki,
  • Sri Aurobindo Prasad Das,
  • Seema Rao,
  • Samiran Nundy,
  • Naimish N. Mehta

摘要

Background

Castleman disease (CD) is a rare lymphoproliferative disorder of unclear etiology, often presenting as an asymptomatic, incidentally detected mass. The predominant pathological variants include hyaline vascular, plasma cell, and mixed types. Clinically, CD is classified into unicentric (UCD) and multicentric (MCD) forms.

Case presentation

Here we report the case of a 34-year-old Indian female with vague left-sided abdominal pain and bilateral lower limb pain, in whom contrast-enhanced CT revealed an incidental well-defined 5.7 × 3.8 × 3.8 cm mass in the gastrohepatic space, initially suggestive of a pancreatic neuroendocrine tumor or gastrointestinal stromal tumor. However, endoscopic ultrasound-guided biopsy indicated a lymphoproliferative neoplasm. Given the discordant imaging and biopsy findings, surgical resection of the mass was undertaken, and the final histopathology confirmed unicentric Castleman disease. No adjuvant therapy was required, and the patient remains disease-free at 2 years of follow-up.

Conclusion

This case underscores the favorable prognosis of UCD—complete surgical resection is associated with near 100% long-term survival—and the importance of differentiating such lesions from other retroperitoneal tumors, which are usually malignant. A thorough preoperative evaluation, including an excisional lymph node biopsy or intraoperative frozen section, is recommended to establish the diagnosis and guide management.