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Background <p>Intracranial hypertension may be idiopathic (IIH) or due to some underlying causes, such as an intracranial space-occupying lesion or drug induced.</p> Case presentation <p>A 14-year-old South Asian male was being treated for MDR-TB with anti-tubercular therapy (including levofloxacin) when he developed a headache lasting 8 days. Examination revealed bilateral papilledema. The CSF study was unremarkable. MRI revealed left transverse and sigmoid sinus stenosis. A probable diagnosis of levofloxacin-induced intracranial hypertension was made, and the drug was stopped. The symptoms resolved within 1 week of drug cessation, and the papilledema resolved within 2&#xa0;weeks.</p> Conclusions <p>Although rare, clinicians must be aware of this side effect of levofloxacin while evaluating a case with recent onset of features of raised ICP and taking this drug as part of some therapy.</p>

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Headache in a case of tuberculosis: think beyond meningitis—a case report

  • 期刊论文

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  • 发表日期：

    2026年4月15日

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  • Sanchit Shailendra Chouksey,
  • Anand Vardhan Sharma,
  • Ekagrata Shukla,
  • Rameshwar Nath Chaurasia,
  • Pratishtha Sengar,
  • Varun Kumar Singh

摘要

Background

Intracranial hypertension may be idiopathic (IIH) or due to some underlying causes, such as an intracranial space-occupying lesion or drug induced.

Case presentation

A 14-year-old South Asian male was being treated for MDR-TB with anti-tubercular therapy (including levofloxacin) when he developed a headache lasting 8 days. Examination revealed bilateral papilledema. The CSF study was unremarkable. MRI revealed left transverse and sigmoid sinus stenosis. A probable diagnosis of levofloxacin-induced intracranial hypertension was made, and the drug was stopped. The symptoms resolved within 1 week of drug cessation, and the papilledema resolved within 2 weeks.

Conclusions

Although rare, clinicians must be aware of this side effect of levofloxacin while evaluating a case with recent onset of features of raised ICP and taking this drug as part of some therapy.