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Background <p>Primary thyroid lymphoma (PTL) is a rare malignant tumor that grows rapidly, with tracheal compression being a common symptom. Surgical removal of the tumor to relieve tracheal compression plays a crucial role in improving the patient’s quality of life.</p> Case presentation <p>We report a case of a 66-year-old female patient of Han ethnicity (China) with primary thyroid diffuse large B&#xa0;cell lymphoma accompanied by tracheal invasion. The patient underwent total thyroidectomy followed by a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy regimen, achieving complete remission of tracheal invasion.</p> Conclusion <p>This case demonstrates the significant value of multidisciplinary collaboration in managing locally advanced primary thyroid lymphoma, which successfully avoided resecting the patient’s trachea and greatly improved their quality of life.</p>

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Multidisciplinary diagnosis and treatment of thyroid diffuse large B cell lymphoma with tracheal invasion: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月7日

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  • Zhiqiang Hu,
  • Zhiling Liu,
  • Jinjie Pan,
  • Qingyang Liu,
  • Yong Ying,
  • Xiangtai Zeng,
  • Yang Xie

摘要

Background

Primary thyroid lymphoma (PTL) is a rare malignant tumor that grows rapidly, with tracheal compression being a common symptom. Surgical removal of the tumor to relieve tracheal compression plays a crucial role in improving the patient’s quality of life.

Case presentation

We report a case of a 66-year-old female patient of Han ethnicity (China) with primary thyroid diffuse large B cell lymphoma accompanied by tracheal invasion. The patient underwent total thyroidectomy followed by a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy regimen, achieving complete remission of tracheal invasion.

Conclusion

This case demonstrates the significant value of multidisciplinary collaboration in managing locally advanced primary thyroid lymphoma, which successfully avoided resecting the patient’s trachea and greatly improved their quality of life.