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Background <p>Prosthetic joint infections are most commonly caused by staphylococci and streptococci, while commensal <i>Neisseria</i> species are exceedingly rare etiologic agents.</p> Case presentation <p>We report a 71-year-old white male with multiple comorbidities who presented with progressive left knee pain 9 years after total knee arthroplasty. Synovial fluid analysis showed an elevated leukocyte count with neutrophil predominance, and cultures subsequently grew <i>Neisseria sicca</i>/<i>subflava</i>. Given the concern for prosthetic joint infection, he underwent prosthesis explantation and received intravenous ceftriaxone 2 g daily for 6 weeks. Poor dentition was identified as a suspected potential source of hematogenous seeding. The patient demonstrated clinical improvement with surgical intervention and targeted antimicrobial therapy.</p> Conclusion <p><i>Neisseria sicca</i>/<i>subflava</i> should be recognized as a rare but clinically significant cause of prosthetic joint infection.</p>

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Prosthetic joint infection caused by Neisseria sicca/subflava

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月2日

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  • Hassaan Abid,
  • Akrum Saleh,
  • Michael DeBrota,
  • Hamza Waheed,
  • Rodney Yuhico,
  • Ritika Zijoo

摘要

Background

Prosthetic joint infections are most commonly caused by staphylococci and streptococci, while commensal Neisseria species are exceedingly rare etiologic agents.

Case presentation

We report a 71-year-old white male with multiple comorbidities who presented with progressive left knee pain 9 years after total knee arthroplasty. Synovial fluid analysis showed an elevated leukocyte count with neutrophil predominance, and cultures subsequently grew Neisseria sicca/subflava. Given the concern for prosthetic joint infection, he underwent prosthesis explantation and received intravenous ceftriaxone 2 g daily for 6 weeks. Poor dentition was identified as a suspected potential source of hematogenous seeding. The patient demonstrated clinical improvement with surgical intervention and targeted antimicrobial therapy.

Conclusion

Neisseria sicca/subflava should be recognized as a rare but clinically significant cause of prosthetic joint infection.