Scholarlink

Background <p>Primary neuroendocrine carcinoma (small-cell carcinoma) of the breast is a rare tumor; most cases are reported in women. Small-cell carcinoma is a type of neuroendocrine tumor characterized by high-grade, poorly differentiated, and aggressive behavior, which are common features regardless of the tumor’s location. Here, we present a rare case of primary small-cell carcinoma of the breast in a male patient treated successfully with neoadjuvant chemotherapy followed by surgery.</p> Case presentation <p>A 47-year-old Syrian man presented with a left breast mass. Further histopathological investigation revealed the diagnosis of high-grade small-cell carcinoma of the breast. Computed tomography imaging excluded other potential primary origins. The patient was treated with neoadjuvant chemotherapy (cisplatin and etoposide), followed by a modified radical mastectomy. After 18&#xa0;months of diagnosis, the patient is under surveillance and doing well.</p> Conclusion <p>This report presents a rare case of male breast cancer with the uncommon histological diagnosis of small-cell carcinoma. It highlights a successful therapeutic approach in the absence of established treatment guidelines.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A complete pathological response to preoperative chemotherapy in a male patient with primary neuroendocrine breast cancer: a case report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月28日

查看全文
  • Maher Saifo,
  • Rahaf Hussein,
  • Eva Awad,
  • Mohamad Al Chikh Youssef,
  • Mousa Alali

摘要

Background

Primary neuroendocrine carcinoma (small-cell carcinoma) of the breast is a rare tumor; most cases are reported in women. Small-cell carcinoma is a type of neuroendocrine tumor characterized by high-grade, poorly differentiated, and aggressive behavior, which are common features regardless of the tumor’s location. Here, we present a rare case of primary small-cell carcinoma of the breast in a male patient treated successfully with neoadjuvant chemotherapy followed by surgery.

Case presentation

A 47-year-old Syrian man presented with a left breast mass. Further histopathological investigation revealed the diagnosis of high-grade small-cell carcinoma of the breast. Computed tomography imaging excluded other potential primary origins. The patient was treated with neoadjuvant chemotherapy (cisplatin and etoposide), followed by a modified radical mastectomy. After 18 months of diagnosis, the patient is under surveillance and doing well.

Conclusion

This report presents a rare case of male breast cancer with the uncommon histological diagnosis of small-cell carcinoma. It highlights a successful therapeutic approach in the absence of established treatment guidelines.