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Background <p>Osteoid osteoma is a benign osteoblastic neoplasm characterized by the production of osteoid and immature bone within a highly vascularized, osteogenic connective tissue stroma. This lesion predominantly occurs in individuals during their second and third decades of life, with a male-to-female predilection ratio of 2:1 to 3:1. This report presents an uncommon case of a giant osteoid osteoma involving the mandibular ramus managed via complete intraoral surgical excision.</p> Case presentation <p>A 24-year-old female of Persian ethnicity presented with a 12-month history of a slowly progressive mass involving the right mandibular ascending ramus and coronoid process. The patient reported a 7-month history of intermittent pain and swelling in the right preauricular region, facial area, and submandibular region. The associated pain exhibited marked alleviation following nonsteroidal anti-inflammatory drug administration. Clinical evaluation, radiographic findings, and physical examination strongly suggested a benign lesion; therefore, surgical intervention was performed via an intraoral approach for complete excisional removal. Intraoperatively, an irregular, solid soft tissue mass measuring 3 × 2 × 0.8&#xa0;cm was successfully resected in its entirety.&#xa0;Histopathological analysis demonstrated thick trabeculae embedded within a vascular connective tissue stroma, accompanied by scattered chronic inflammatory infiltrates and prominent blood vessels surrounding the nidus. The lesion exhibited multiple nidi with heterogeneous architecture, including a sclerotic network of bone trabeculae. These findings confirmed the diagnosis of osteoid osteoma.</p> Conclusion <p>In this case, a rare giant osteoid osteoma was effectively excised using an intraoral approach, resulting in significant improvement in both facial swelling and mouth opening, with no major postoperative complications.</p>

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Giant osteoid osteoma of mandible in a 24-year-old female: a case report

  • 期刊论文

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  • 发表日期：

    2025年12月15日

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  • Hassan Mirmohammad Sadeghi,
  • Faezeh Kashi,
  • Fatemeh Mashhadiabbas,
  • Milad Baseri,
  • Maryam Mohammadalizadeh Chafjiri,
  • Mostafa Alam,
  • Ramin Ansari,
  • Parnian Nikraftar,
  • Ardeshir Khorsand

摘要

Background

Osteoid osteoma is a benign osteoblastic neoplasm characterized by the production of osteoid and immature bone within a highly vascularized, osteogenic connective tissue stroma. This lesion predominantly occurs in individuals during their second and third decades of life, with a male-to-female predilection ratio of 2:1 to 3:1. This report presents an uncommon case of a giant osteoid osteoma involving the mandibular ramus managed via complete intraoral surgical excision.

Case presentation

A 24-year-old female of Persian ethnicity presented with a 12-month history of a slowly progressive mass involving the right mandibular ascending ramus and coronoid process. The patient reported a 7-month history of intermittent pain and swelling in the right preauricular region, facial area, and submandibular region. The associated pain exhibited marked alleviation following nonsteroidal anti-inflammatory drug administration. Clinical evaluation, radiographic findings, and physical examination strongly suggested a benign lesion; therefore, surgical intervention was performed via an intraoral approach for complete excisional removal. Intraoperatively, an irregular, solid soft tissue mass measuring 3 × 2 × 0.8 cm was successfully resected in its entirety. Histopathological analysis demonstrated thick trabeculae embedded within a vascular connective tissue stroma, accompanied by scattered chronic inflammatory infiltrates and prominent blood vessels surrounding the nidus. The lesion exhibited multiple nidi with heterogeneous architecture, including a sclerotic network of bone trabeculae. These findings confirmed the diagnosis of osteoid osteoma.

Conclusion

In this case, a rare giant osteoid osteoma was effectively excised using an intraoral approach, resulting in significant improvement in both facial swelling and mouth opening, with no major postoperative complications.