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Background <p>Despite advances in depression research and treatment, effective strategies based on clear neural mechanisms are still lacking. Current therapies often show delayed effects and inconsistent outcomes, suggesting that the core pathophysiology remains unclear.</p> Case presentation <p>This case report describes a highly successful and rapid resolution of subacute mild anxiety and severe depression in a 32-year-old woman of Chinese origin following treatment with potassium ion supplementation. It explores the potential mechanisms underlying this therapeutic effect, highlighting the role of relative potassium ion deficiency in the pathogenesis of depression.</p> Conclusion <p>This case achieved significant therapeutic outcomes through innovative treatment strategies, raising an interesting possibility on the pathogenesis of depression. However, more clinical observations or cohort studies are needed to support this finding.</p>

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Rapid treatment of depression with potassium supplementation: relative deficiency of potassium ions and possible pathogenesis—a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月28日

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  • Jiapei Dai

摘要

Background

Despite advances in depression research and treatment, effective strategies based on clear neural mechanisms are still lacking. Current therapies often show delayed effects and inconsistent outcomes, suggesting that the core pathophysiology remains unclear.

Case presentation

This case report describes a highly successful and rapid resolution of subacute mild anxiety and severe depression in a 32-year-old woman of Chinese origin following treatment with potassium ion supplementation. It explores the potential mechanisms underlying this therapeutic effect, highlighting the role of relative potassium ion deficiency in the pathogenesis of depression.

Conclusion

This case achieved significant therapeutic outcomes through innovative treatment strategies, raising an interesting possibility on the pathogenesis of depression. However, more clinical observations or cohort studies are needed to support this finding.