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Introduction <p>Hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome are severe complications of pregnancy with potentially life-threatening consequences. Currently, the timely recognition and management of pregnant women with hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome remains a challenge.</p> Case presentation <p>In this case, we describe a 28-year-old East Asian pregnant woman with a history of antiphospholipid syndrome who developed hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome after delivery at 36&#xa0;weeks of pregnancy. The patient presented with multiple red spots on her extremities and despite receiving conventional therapy, her condition deteriorated rapidly postpartum leading to multiple organ dysfunction syndrome. Notably, the onset of multiple organ dysfunction syndrome occurred within a narrow timeframe of 11&#xa0;hours.</p> Conclusion <p>This case underscores the importance of the early warning value of skin manifestations. At the same time, it is crucial to closely monitor pregnant women with antiphospholipid syndrome both during and after delivery. Furthermore, the rapid onset and progression of multiple organ dysfunction syndrome highlight the critical need for prompt initiation of organ support measures in such situations.</p>

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A new tip for early warning of catastrophic antiphospholipid syndrome and hemolysis, elevated liver enzymes, and low platelet count syndrome: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Ran Teng,
  • Nan Zheng,
  • Ruixuan Yu,
  • Fengchan Xi

摘要

Introduction

Hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome are severe complications of pregnancy with potentially life-threatening consequences. Currently, the timely recognition and management of pregnant women with hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome remains a challenge.

Case presentation

In this case, we describe a 28-year-old East Asian pregnant woman with a history of antiphospholipid syndrome who developed hemolysis, elevated liver enzymes, and low platelet count syndrome and catastrophic antiphospholipid syndrome after delivery at 36 weeks of pregnancy. The patient presented with multiple red spots on her extremities and despite receiving conventional therapy, her condition deteriorated rapidly postpartum leading to multiple organ dysfunction syndrome. Notably, the onset of multiple organ dysfunction syndrome occurred within a narrow timeframe of 11 hours.

Conclusion

This case underscores the importance of the early warning value of skin manifestations. At the same time, it is crucial to closely monitor pregnant women with antiphospholipid syndrome both during and after delivery. Furthermore, the rapid onset and progression of multiple organ dysfunction syndrome highlight the critical need for prompt initiation of organ support measures in such situations.