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Background <p>Acquired hemophilia A is a rare autoimmune disease characterized by inhibitory antibodies against coagulation factor VIII, leading to an increased risk of bleeding. The relevance of this case lies in its high associated morbidity and mortality, and the importance of early diagnosis in both medical and dental practice.</p> Case presentation <p>We present the clinical case of a 74-year-old Spanish Caucasian patient diagnosed with acquired hemophilia A. The patient was initially treated for progressive edema in the right lower limb, followed by hematomas in the tongue and submandibular region. The diagnosis was confirmed through hematological tests, which revealed a prolonged activated partial thromboplastin time and low coagulation factor VIII activity (2.4%). Treatment with hemostatic agents and corticosteroids was initiated, resulting in a favorable improvement of the hematomas. </p> Conclusions <p>Acquired hemophilia A requires a multidisciplinary and personalized approach for each patient. Focus should be placed on prevention, early diagnosis, and appropriate treatment to effectively manage this coagulopathy and improve patient outcomes.</p>

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Acquired hemophilia A: a case report and review of the literature

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Juan-Alfonso Perotti-Abad,
  • Álvaro Cabezas-Corado,
  • Luis Astolfi-Labrador,
  • María Baus-Domínguez,
  • Guillermo Machuca-Portillo,
  • María-Ángeles Serrera-Figallo,
  • Daniel Torres-Lagares

摘要

Background

Acquired hemophilia A is a rare autoimmune disease characterized by inhibitory antibodies against coagulation factor VIII, leading to an increased risk of bleeding. The relevance of this case lies in its high associated morbidity and mortality, and the importance of early diagnosis in both medical and dental practice.

Case presentation

We present the clinical case of a 74-year-old Spanish Caucasian patient diagnosed with acquired hemophilia A. The patient was initially treated for progressive edema in the right lower limb, followed by hematomas in the tongue and submandibular region. The diagnosis was confirmed through hematological tests, which revealed a prolonged activated partial thromboplastin time and low coagulation factor VIII activity (2.4%). Treatment with hemostatic agents and corticosteroids was initiated, resulting in a favorable improvement of the hematomas.

Conclusions

Acquired hemophilia A requires a multidisciplinary and personalized approach for each patient. Focus should be placed on prevention, early diagnosis, and appropriate treatment to effectively manage this coagulopathy and improve patient outcomes.