Successful administration of cetuximab using dose escalation method: a case report

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2024年10月17日

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Shasha Li,
Yanjuan Zhang,
Jiandong Zha,
Wenqi Chen

摘要

Introduction

Cetuximab, used to treat head and neck squamous cell carcinoma and metastatic colorectal cancer, can cause severe infusion reactions.

Case presentation

We report an 87-year-old East Asian woman with stage IV ileocecal signet ring cell carcinoma who experienced severe allergic reactions to cetuximab despite pre-treatment. A dose escalation method, involving weekly incremental doses with comprehensive pre-treatment and close monitoring, was employed, successfully reducing allergic reactions and allowing safe administration.

Conclusion

This approach demonstrates a viable alternative for patients with hypersensitivity to cetuximab, warranting further research for personalized treatment optimization.