Background <p>Stevens–Johnson syndrome epitomizes an acute, exceptionally rare, and capricious immunological phenomenon marked by potentially life-threatening skin reactions, involvement of mucous membranes, and concomitant systemic manifestations. Most cases of Stevens–Johnson syndrome have been attributed to being triggered by drugs, while a minority have implicated infectious agents such as&#xa0;Mycoplasma pneumoniae and Coxsackie virus A6 as their cause. We present a case report on the rare occurrence of Mycoplasma-pneumoniae-induced Stevens–Johnson Syndrome in a 25-year-old Sri Lankan male adult.</p> Case presentation <p>A 25-year-old Sri Lankan male adult sought medical attention at our institution, presenting a constellation of symptoms composed of fever with chills, dyspnea, pleuritic chest pain, cough producing reddish sputum, and sore throat, persisting over a 4-day period; 2 days following the onset of the respiratory symptoms, he experienced ocular congestion with purulent discharge and painful oral lesions. He had associated generalized body ache and fatigue.</p> <p>Stevens-Johnson syndrome is diagnosed by skin biopsy.</p> Conclusion <p>Stevens–Johnson syndrome is an acute and debilitating condition that requires prompt and timely management to ensure minimum morbidity of the patient. The similarities and overlap of features between Stevens–Johnson syndrome caused due to infectious and drug-related etiologies pose a diagnostic challenge for the physicians, which needs to be subdued using systematic research and evaluation with subsequent formulation of an evidence-based assessment and management plan to ensure safe and efficacious medical care for the patients.</p>