Abstract <p>Reporting and Data Systems (RADS) aim at standardizing imaging acquisition, interpretation, lexicon, and reporting standards in specific patient populations, facilitating the communication between radiologists and clinicians. While the adoption of RADS has been supported by several studies and guidelines, with some of them endorsed by the American College of Radiology, the clinical adoption of the RADS algorithm remains heterogeneous among general practice radiologists worldwide, being lower in non-academic and young radiologists. This article aims to provide an updated review, aimed at young and general radiologists, of the RADS alphabet, discussing the main applications and imaging criteria with tips for their correct use in clinical practice. The following RADS will be discussed: BI-RADS, Bone-RADS, C-RADS, CAD-RADS, LI-RADS, Lung-RADS, MET-RADS-P, MY-RADS, NI-RADS, Node-RADS, O-RADS, ONCO-RADS, PI-RADS, ST-RADS, TI-RADS, and VI-RADS.</p> Critical relevance statement <p>A comprehensive guide aimed at young and general radiologists featuring all of the major RADS with the objective to foster their implementation in clinical practice, which could be beneficial in a further standardization of the medical reports and in the communication between radiologists and clinicians.</p> Key Points <p><UnorderedList Mark="Bullet"> <ItemContent> <p>RADS are outlined to enhance communication efficacy between radiologists and clinicians.</p> </ItemContent> <ItemContent> <p>Updated overview of RADS frameworks, detailing applications, imaging criteria, and advancements.</p> </ItemContent> <ItemContent> <p>RADS’ implementation remains a challenge, but can be addressed.</p> </ItemContent> </UnorderedList></p> Graphical Abstract <p></p>