Objectives To quantitatively assess the degeneration of paraspinal and pelvic muscles in patients with lumbar disc herniation (LDH) using MRI q-Dixon and to explore their potential association with LDH. Materials and methods The cross-sectional area (CSA) and proton density fat fraction (PDFF) of the multifidus (MF), erector spinae (ES), psoas major (PM), and gluteus medius (GM), as well as the vertebral bone marrow fat fraction (BMFF), lumbar lordosis (LL), and sacral slope (SS), were measured in both LDH and control groups. Results A total of 85 LDH patients and 48 controls were included. No significant differences in CSA were observed between groups (all p > 0.05). However, PDFF values were significantly higher in the LDH group for all muscles compared to controls (all p < 0.05). After adjustment, the PDFF differences in MFL4/5, ESL4/5, PML3/4, and PML4/5 remained statistically significant (p < 0.05). Although bilateral muscle asymmetry was observed in several muscles, these differences were no longer significant after adjustment (p > 0.05). No significant differences in VBFF, LL, or SS were found (all p > 0.05). Conclusions LDH patients exhibit increased fat infiltration in the MF, ES, PM, and GM compared to controls, suggesting a potential association between pelvic and paraspinal muscle degeneration and LDH. Critical relevance statement The MRI q-Dixon technique effectively and noninvasively detects early degeneration of the paraspinal muscles and GM, indicating their potential association with LDH and enabling more targeted rehabilitation strategies. Key Points <UnorderedList Mark="Bullet"> <ItemContent> Spine and muscle changes affect LDH, but their relationship remains unclear. </ItemContent> <ItemContent> Fat infiltration is more sensitive than CSA for detecting muscle degeneration. </ItemContent> <ItemContent> LDH patients exhibit greater paraspinal muscle and GM degeneration. </ItemContent> </UnorderedList> Graphical Abstract

Paraspinal muscles and gluteus medius fat infiltration are both associated with lumbar disc herniation

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2025年8月14日

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Jianping Wang,
Zhenhua Zhao,
Ding Liang,
Xiao Xu,
Dingbo Shu

摘要

Objectives

To quantitatively assess the degeneration of paraspinal and pelvic muscles in patients with lumbar disc herniation (LDH) using MRI q-Dixon and to explore their potential association with LDH.

Materials and methods

The cross-sectional area (CSA) and proton density fat fraction (PDFF) of the multifidus (MF), erector spinae (ES), psoas major (PM), and gluteus medius (GM), as well as the vertebral bone marrow fat fraction (BMFF), lumbar lordosis (LL), and sacral slope (SS), were measured in both LDH and control groups.

Results

A total of 85 LDH patients and 48 controls were included. No significant differences in CSA were observed between groups (all p > 0.05). However, PDFF values were significantly higher in the LDH group for all muscles compared to controls (all p < 0.05). After adjustment, the PDFF differences in MF_L4/5, ES_L4/5, PM_L3/4, and PM_L4/5 remained statistically significant (p < 0.05). Although bilateral muscle asymmetry was observed in several muscles, these differences were no longer significant after adjustment (p > 0.05). No significant differences in VBFF, LL, or SS were found (all p > 0.05).

Conclusions

LDH patients exhibit increased fat infiltration in the MF, ES, PM, and GM compared to controls, suggesting a potential association between pelvic and paraspinal muscle degeneration and LDH.

Critical relevance statement

The MRI q-Dixon technique effectively and noninvasively detects early degeneration of the paraspinal muscles and GM, indicating their potential association with LDH and enabling more targeted rehabilitation strategies.

Key Points

Spine and muscle changes affect LDH, but their relationship remains unclear.

Fat infiltration is more sensitive than CSA for detecting muscle degeneration.

LDH patients exhibit greater paraspinal muscle and GM degeneration.

Graphical Abstract