Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI

期刊论文
出版模式：

开放获取
发表日期：

2024年7月2日

查看全文

Shengfang Xu,
Zihan Ma,
Jinlong Zhang,
Shaoyu Wang,
Xin Ge,
Songhong Yue,
Xinyi Li,
Jifang Qian,
Dalin Zhu,
Guangyao Liu,
Jing Zhang

摘要

Objectives

This study investigated the quantitative assessment and application of Synthetic MRI (SyMRI) for preoperative brain development in children with congenital heart disease (CHD).

Methods

Forty-three CHD patients aged 2–24 months were prospectively included in the observation group, and 43 healthy infants were included in the control group. The SyMRI scans were processed by postprocessing software to obtain T1, T2, and PD maps. The values of T1, T2, and PD in different brain regions were compared with the scores of the five ability areas of the Gesell Development Scale by Pearson correlation analysis.

Results

In the observation group, the T1 values of the posterior limb of the internal capsule (PLIC), Optic radiation (PTR), cerebral peduncle, centrum semiovale, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. In the observation group, the T2 values of the PLIC, PTR, frontal white matter, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. Pearson correlation analysis revealed that the observation group had significantly lower Development Scale scores. In the observation group, the T2 value of the splenium of the corpus callosum was significantly positively correlated with the personal social behavior score. The AUCs for diagnosing preoperative brain developmental abnormalities in children with CHD using T1 values of the temporal white matter and dentate nucleus were both greater than 0.60.

Conclusions

Quantitative assessment using SyMRI can aid in the early detection of preoperative brain development abnormalities in children with CHD.

Critical relevance statement

T1 and T2 relaxation values from SyMRI can be considered as a quantitative imaging marker to detect abnormalities, allowing for early clinical evaluation and timely intervention, thereby reducing neurodevelopmental disorders in these children.

Key Points

T1 and T2 relaxation values by SyMRI are related to myelin development.

Evaluated development quotient markers were lower in the observation compared to the control group.

SyMRI can act as a reference indicator for brain development in CHD children.

Graphical Abstract