<p>Allergen immunotherapy (AIT) is an essential disease-modifying therapy in the field of allergy and clinical immunology. The Immunotherapy Manual of the Canadian Society of Allergy and Clinical Immunology serves as a comprehensive guide for the safe and effective administration of immunotherapy. Its purpose is to address an educational gap in immunotherapy identified by residency training programs in Canada.</p><p>This summary highlights key updates for both aeroallergen and venom immunotherapy from the latest edition of the immunotherapy manual and provides a concise, accessible resource for trainees to support their practice. The areas reviewed include principles of immunotherapy, allergen extract standardization, and safety related to immunotherapy with practical strategies for risk mitigation. Included in the original manual are practice cases that have been updated with systematic checklists to coach readers in their management of patients.</p><p>The updated immunotherapy manual and its summary aim to serve as a basis for trainees as they develop competence in the provision of immunotherapy.</p>